Generic
Meclizine Hydrochloride + Pyridoxine Hydrochloride
29 brands available in the market
At a glance
Meclizine Hydrochloride + Pyridoxine Hydrochloride is a combination medicine used for vertigo and motion sickness. It prevents nausea, vomiting, light-headedness, and other symptoms of vertigo.
Description
Meclizine is a piperazine-derivative antihistamine with antiemetic, anticholinergic, and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. Pyridoxine (vitamin B6) is a water-soluble vitamin that functions in carbohydrate, protein, and fat metabolism and enhances the anti-emetic effects.
Indications
- Vertigo
- Motion sickness
- Prevention and treatment of nausea and vomiting
- Radiation sickness
Therapeutic class
Anti-emetic Drugs
Pharmacological class
Antihistamine + Vitamin B6
Pharmacology
Meclizine reduces labyrinthine apparatus sensitivity to block vomiting signals; Pyridoxine enhances anti-emetic effects and acts as a dietary supplement.
Mechanism of action
Controls nausea, vomiting, and dizziness.
Dosage
Adults and Children 12 years+:
- Motion sickness: 25-50 mg (meclizine), 1 hour before travel; repeat every 24 hours if needed
- Vertigo: 25-100 mg daily in divided doses
- Radiation sickness: 50 mg, 2-12 hours prior to radiation treatment
- Pyridoxine: 50-200 mg/day
Administration
- Swallow tablet whole; do not chew, crush or break
- May be taken with or without food, but at a fixed time is preferable
- Take 1 hour before travel
Missed dose
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Side effects
Common Side Effects:
- Dry mouth
- Allergic reaction
- Drowsiness
- Headache
- Fatigue
- Blurred vision (rare)
Precautions & warnings
- Caution when driving or doing activities requiring concentration (may cause drowsiness and dizziness)
- Avoid alcohol (may cause excessive drowsiness)
- Do not use with other sedating medications (cough and cold medicines)
- Caution in asthma, glaucoma, or prostate enlargement
- Consult doctor during pregnancy and lactation
Contraindications
- Hypersensitivity to Meclizine or Pyridoxine
Drug interactions
- Additive effects with CNS depressants, neuroleptics, anticholinergics, and alcohol
- May increase absorption of digoxin (by decreasing GI motility)
Food interactions
Caution is advised when consuming alcohol with Meclizine + Pyridoxine; consult your doctor.
Use in pregnancy
Use in Pregnancy: Meclizine + Pyridoxine is generally considered safe during pregnancy (Category B); large-scale human studies have not demonstrated adverse fetal effects; it is the drug of first choice for nausea and vomiting during pregnancy.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Meclizine + Pyridoxine is probably safe during breastfeeding; limited human data suggests no significant risk to the baby; larger doses or prolonged use may cause sleepiness in the baby.
Pediatric use
Safety and efficacy not established in children under 12 years.
Geriatric use
Caution needed in elderly.
Renal / hepatic impairment
Renal Impairment: Probably safe in kidney disease; dose adjustment may not be needed.
Hepatic Impairment: Probably safe in liver disease; dose adjustment may not be needed.
Overdose effects
Overdose may cause extreme excitability, seizures, drowsiness, and hallucinations; supportive and symptomatic treatment; consider dialysis.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.
Chemical structure
Meclizine Hydrochloride + Pyridoxine Hydrochloride