Generic
Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B Vag
11 brands available in the market
At a glance
Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B Vaginal suppository is used for vaginal trichomoniasis leucorrhoea and mixed vaginal infections.
Description
This combination contains Metronidazole against anaerobic bacteria and protozoa. Nystatin binds to ergosterol in fungal cell membrane. Polymyxin B disrupts gram-negative bacterial membrane. Neomycin inhibits protein synthesis by binding to 30S ribosomal subunits.
Indications
- Vaginal trichomoniasis
- Vaginal leucorrhoea
- Bacterial or fungal vaginal infection
- Mixed vaginal infections
Therapeutic class
Drugs used in Vaginal and Vulval conditions
Pharmacological class
Antibiotic + Antifungal Combination
Pharmacology
Metronidazole interacts with DNA causing destruction of helical structure. Nystatin binds to ergosterol affecting cell wall permeability. Polymyxin B disrupts bacterial cytoplasmic membrane. Neomycin binds to 30S ribosomal subunits inhibiting protein synthesis.
Mechanism of action
Stops the growth of bacteria and fungi causing infection.
Dosage
Adult Dose (Vaginal Suppository):
- Insert 1 suppository into the vagina at bedtime
- Use for 12 days
Administration
- Insert high up into the vagina at bedtime
- Wash hands before and after application
- For vaginal use only
Missed dose
Not applicable (topical preparation)
Side effects
Side Effects:
- Skin rash and urticaria (rare)
- Local irritation (rare)
Precautions & warnings
- Caution in renal impairment
- Discontinue if sensitization occurs
- For external use only
Contraindications
- Hypersensitivity to any component
- Severe renal impairment
Food interactions
Food interaction not applicable (topical preparation)
Use in pregnancy
Use in Pregnancy: Caution advised. Animal studies show adverse effects on fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Caution advised.
Pediatric use
Safety and efficacy in children not established.
Geriatric use
No specific dose adjustment for elderly.
Renal / hepatic impairment
Renal Impairment: Caution in renal impairment.
Overdose effects
No overdose information available (topical preparation).
Storage conditions
Store in a cool and dry place away from light. Keep out of reach of children.
Chemical structure
Metronidazole + Neomycin + Nystatin + Polymyxin B Vag