Generic
Mirogabalin Besylate
59 brands available in the market
At a glance
Mirogabalin Besylate is a neuropathic pain medication used for diabetic peripheral neuropathic pain and postherpetic neuralgia.
Description
Mirogabalin Besylate selectively binds to α2δ subunits of voltage-gated calcium channels reducing calcium influx and inhibiting neurotransmitter release.
Indications
- Neuropathic Pain
- Diabetic Peripheral Neuropathic Pain (DPNP)
- Postherpetic Neuralgia (PHN)
- Peripheral Neuropathic Pain (PNP)
Therapeutic class
Adjunct anti-epileptic drugs and Primary anti-epileptic drugs
Pharmacological class
Gamma Amino Acid and its Derivatives
Pharmacology
Mirogabalin Besylate binds to α2δ subunits of voltage-gated calcium channels reducing calcium influx and inhibiting neurotransmitter release.
Mechanism of action
Reduces calcium influx to inhibit neurotransmitter release and relieve pain.
Dosage
Adult Dose (Oral):
- Initial Dose: 5 mg twice daily
- Titration: Increase by 5 mg weekly to 15 mg twice daily
- Maintenance: 10-15 mg twice daily (based on age and symptoms)
Mild Renal Impairment: 5 mg twice daily → 10 mg twice daily
Moderate Renal Impairment: 2.5 mg twice daily → 7.5 mg twice daily
Severe Renal Impairment: 2.5 mg once daily → 7.5 mg once daily
Administration
- May be taken with or without food
- Swallow tablet whole
- Titrate dose as per doctor's advice
Missed dose
Not applicable (specific titration schedule)
Side effects
Common Side Effects:
- Somnolence (drowsiness)
- Dizziness
- Edema
- Weight gain
- Loss of consciousness (rare)
- Liver dysfunction (rare)
Precautions & warnings
- Caution while driving (may cause drowsiness and dizziness)
- Elderly patients caution (risk of falling)
- Avoid alcohol
- Dose adjustment needed in renal impairment
Contraindications
- Hypersensitivity to Mirogabalin
- Mild to moderate hepatic and renal impairment
Drug interactions
- Cimetidine or Probenecid: Increased plasma concentration
- Lorazepam or Alcohol: Potentiated CNS depression
Food interactions
Alcohol with Mirogabalin Besylate may cause excessive drowsiness.
Use in pregnancy
Use in Pregnancy: Safety information not available. Use only if needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Safety information not available. Caution advised.
Pediatric use
Safety and efficacy in children and adolescents not established.
Geriatric use
Elderly patients require special caution (risk of falling).
Renal / hepatic impairment
Renal Impairment: Mild: 5 mg bid → 10 mg; Moderate: 2.5 mg bid → 7.5 mg; Severe: 2.5 mg once daily → 7.5 mg once daily.
Hepatic Impairment: Mild-moderate: no dose adjustment; Severe: no data available.
Overdose effects
No overdose information available. Symptomatic and supportive treatment.
Storage conditions
Store below 30°C in a dry place away from light and moisture. Keep out of reach of children.
Chemical structure
Mirogabalin Besylate