Moxifloxacin IV

Moxifloxacin IV is an antibiotic, used in the treatment of bacterial infections. It is also used in treating infections of the urinary tract, nose, throat, skin and soft tissues and lungs (pneumonia). It cures the infection by stopping further growth of the causative microorganisms. Moxifloxacin IV is given as an injection into a vein (intravenous), in cases where oral administration is not possible, such as in hospitalised or unconscious patients. It is administered by a healthcare professional. Kindly do not self administer. Avoid skipping any doses and finish the full course of treatment even if you feel better. Some people may have a headache, dizziness, nausea, and diarrhea as side effects of this medicine. You may also notice some injection site reactions like pain, swelling or redness. These are usually temporary and resolve on their own, but please consult your doctor if these side effects persist for a longer duration. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools. You should not take this medicine if you are allergic to any of its ingredients. Special care should be taken in people with kidney problems while taking this medicine. Moxifloxacin IV is an antibiotic. It works by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them.

• Bacterial infections

Moxifloxacin inhibits the topoisomerase II (DNA gyrase) and topoisomerase IV required for bacterial DNA replication, transcription, repair and recombination.

Adult Dose: Moxifloxacin 400 mg IV infusion can be administered intravenously once daily for 5-21 days, depending on the condition. The duration of therapy depends on the type of infection as described bellow- Intravenous Acute bacterial sinusitis Adult: 400 mg once daily infused over 60 min for 10 days. Acute bacterial exacerbation of chronic bronchitis Adult: 400 mg once daily infused over 60 min for 5 days. Community-acquired pneumonia Adult: 400 mg once daily infused over 60 min for 7-14 days. Skin and skin structure infections Adult: Complicated: 400 mg once daily for 7-21 days; uncomplicated: 400 mg once daily for 7 days. Doses to be infused over 60 min. Intra-abdominal infections Adult: 400 mg once daily infused over 60 min for 5-14 days. May change to oral therapy when clinically appropriate. Elderly: No adjustment of dosage is required in the elderly. Child Dose: <18 years: Safety and efficacy not established

Your doctor or nurse will give you this medicine. Kindly do not self-administer.

If you miss a dose of Moxifloxacin IV, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Headache • Dizziness • Nausea • Diarrhea

[UNSAFE] Moxifloxacin IV may cause side effects which could affect your ability to drive. Moxifloxacin IV may make you feel dizzy or light-headed, you may experience a sudden, transient loss of vision, or you may faint for a short period. This may affect your driving ability. Your doctor has prescribed Moximac IV 400mg Infusion to cure your infection and improve symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Discontinue Moximac IV 400mg Infusion and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools. Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations. Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Known hypersensitivity to moxifloxacin, other quinolones. Patients w/ known prolongation of QT interval, uncorrected hypokalaemia, myasthenia gravis. Concurrent use of class Ia (e.g.quinidine, procainamide, class III (e.g. amiodarone, sotalol) antiarrhythmic drugs or w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents).

Additive effect on QT interval prolongation w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents). Decreased absorption and bioavailability w/ Al- or Mg-containing antacids, or Fe or Zn preparations. Concomitant use of corticosteroids increases the risk of severe tendon disorders esp in elderly (>60 yr). Decreased absorption w/ sucralfate or didanosine. Potentially Fatal: Concurrent use of class Ia (e.g. quinidine, procainamide) or III (e.g. amiodarone, sotalol) antiarrhythmic drugs or w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents) may cause additive effect on QT interval prolongation.

[SAFE] Consuming alcohol with Moxifloxacin IV does not cause any harmful side effects.

[CONSULT YOUR DOCTOR] Moxifloxacin IV may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Moxifloxacin IV is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[SAFE IF PRESCRIBED] Moxifloxacin IV is safe to use in patients with kidney disease. No dose adjustment of Moxifloxacin IV is recommended. However, inform your doctor if you have any underlying kidney disease. [CAUTION] Moxifloxacin IV should be used with caution in patients with severe liver disease. Dose adjustment of Moxifloxacin IV may be needed. Please consult your doctor. Limited information is available on the use of Moxifloxacin IV in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.

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