Pralidoxime Chloride

Pralidoxime Chloride is a prescription medicine used in the treatment of poisoning caused by pesticides and chemicals that contain organophosphates. It is used in the cases where respiratory depression occurs as a result of muscle weakness due to poisoning. Pralidoxime Chloride is administered in a medical emergency situation thus aim should be to seek treatment of poisoning without waiting for the results of laboratory tests. This injection is given under the supervision of a healthcare professional. Moreover, it is important to consult your doctor if you have abnormal heartbeat, difficulty or trouble with breathing, increased muscle weakness, or severe tiredness after receiving this medicine. There can be some side effects like nausea, muscle weakness, headache, double vision, and blurred vision. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you will better. This medicine may also increase your blood pressure, so it is better to consult your doctor if it bothers you. Pralidoxime Chloride reactivates the enzymes blocked by many pesticides (organophosphates). It is an antidote used in the poisoning of these pesticides.

• Organophosphate poisoning

Pralidoxime reactivates cholinesterase outside the CNS which has been inactivated by phosphorylation due to organophosphate pesticide exposure-resulting. This leads to the destruction of acetylcholine at the neuromuscular junction thus relieving muscle paralysis. It also removes the phosphyl group from the active site of inactivated enzyme which is dependent on the nature of the phosphyl group.

Adult Dose: Organophosphorous Poisoning For IV Infusion: Adults: 1-2 g IV as 15-30 min infusion, repeat a second dose of 1 g to 2 g may be indicated after about one hour if muscle weakness has not been relieved. Additional doses may be given every 10-12 hours if muscle weakness persists. OR Use with atropine, which affects muscarinic receptors; pralidoxime's actions most striking at nicotonic sites (increase muscle strength 10-40 min) For IV Injection: For fluid restricted patient 1 g, should be slowly given (over not less than 5 minutes) by IV injection, as 50 mg/ml solution in normal saline (e.g. 1 g in 20 ml). IM: 600 mg IM x3 doses; administer each dose 15 minutes apart for mild symptoms, or in rapid succession for severe symptoms Acetylcholinesterase Inhibitor Toxicity Initial: 30 mg/kg IV (IM, SC if no IV access) over 20 min 4-8 mg/kg/hr IV infusion Child Dose: Organophosphorous Poisoning For IV Infusion: Children > 16 years of age: 1-2 g IV as 15-30 min infusion, repeat a second dose of 1 g to 2 g may be indicated after about one hour if muscle weakness has not been relieved. Additional doses may be given every 10-12 hours if muscle weakness persists. OR Use with atropine, which affects muscarinic receptors; pralidoxime's actions most striking at nicotonic sites (increase muscle strength 10-40 min) For IV Injection: For fluid restricted patient 1 g, should be slowly given (over not less than 5 minutes) by IV injection, as 50 mg/ml solution in normal saline (e.g. 1 g in 20 ml). Children < 16 years of age: Loading dose: 20-50 mg/kg (maximum: 2000 mg/dose); Maintenance infusion: 10-20 mg/kg/hour; alternatively, a repeat bolus of 20-50 mg/kg (maximum 2000 mg/dose) may be administered after 1 hour and repeated every 10-12 hours thereafter, as needed. IM administration <40 kg: 15 mg/kg/dose IM x3 doses 40 kg or greater: Administer as in adults; 600 mg/dose IM x3 doses Renal Dose: Renal Impairment: Reduce dose

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Pralidoxime Chloride, please consult your doctor.

Common: • Accomodation disorder • Dizziness • Double vision • Drowsiness • Headache • High blood pressure • Increased heart rate • Muscle weakness • Nausea

[CONSULT YOUR DOCTOR] It is not known whether Pralidoxime Chloride alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Pralidoxime Chloride is given as an injection into veins, muscles or under the skin by a doctor only. Your doctor will monitor you closely for a period of 72 hours after giving the medicine. Your doctor will closely monitor your heart rate, blood pressure, breathing rate and oxygen level during the treatment. It may cause temporary blurring of your vision. Do not drive or do anything that requires concentration until you know how it affects you.

Carbamate pesticide poisoning, hypersensitivity.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Pralidoxime Chloride. Please consult your doctor.

[CONSULT YOUR DOCTOR] Pralidoxime Chloride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CAUTION] Pralidoxime Chloride should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

[CAUTION] Pralidoxime Chloride should be used with caution in patients with kidney disease. Dose adjustment of Pralidoxime Chloride may be needed. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Pralidoxime Chloride in patients with liver disease. Please consult your doctor.

Food poisoning related problem Consult doctor for this Stomach pain due to food poisoning. Tab Drotin 1 SOS, Tab O2 H 1 BD x 3 days Pl suggest the medicine for food poisoning If you are having diarrhoea and vomiting , please take ORS and visit to your doctor to assess the hydration status and decide the medications after that Leg pain and frequent food poisoning Your Question is not clear to me . Please ask your question more clearly and in detail and also try be more specific and descriptive. Food poisoning, vomiting and loose motion ORS, Tab Zenflox Oz 1 BD x 3 days Reamody of stomach pain because food poisoning There are many underlying causes of your symptoms. Different cause needs different treatment. Specific treatment cannot be given unless we establish exact underlying cause. Diagnosis can not be done without clinical examination. Please visit me or any other Paediatrician. will take detail history and will examine your child in detail. At time may ask you relevant investigations if necessary. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment. Your child may need antibiotics. It is mandatory for the customer to have a prescription for the medicines he/she is procuring. Valid prescription cannot be given without diagnosis. Food poisoning ( vomiting, diarrhea,fever & body Ache Tab Pacimol 1 SOS, Tab Domstal 1 Stat, Tab O2 H 1 BD x 3 days