Thiotepa

Thiotepa is used in the treatment of cancers of brain, breast, lungs, and ovaries. It is used in combination with other cancer medicine during hematopoietic progenitor cell transplantation (HPCT). It may be also used to treat other conditions, as determined by the doctor. Thiotepa is given as an IV infusion under the supervision of a healthcare professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, vomiting, hair loss, and mouth sores. Some serious side effects, which means they need immediate action involve anemia (low number of red blood cells). This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Thiotepa is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

• Brain tumor • Breast cancer • Non-small cell lung cancer • Ovarian cancer

Thiotepa is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Thiotepa, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Mucosal inflammation • Anemia (low number of red blood cells) • Low blood platelets • Decreased white blood cell count (neutrophils)

[UNSAFE] Thiotepa may cause side effects which could affect your ability to drive. It is likely that certain adverse events of Thiotepa are dizziness, headache, and blurred vision which could affect your ability to drive.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Thiotepa. Please consult your doctor.

[CONSULT YOUR DOCTOR] Thiotepa is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Thiotepa is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[SAFE IF PRESCRIBED] Thiotepa is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Thiotepa may not be needed in these patients. Please consult your doctor. [CAUTION] Thiotepa should be used with caution in patients with liver disease. Dose adjustment of Thiotepa may be needed. Please consult your doctor. Regular monitoring of liver function tests may be advised while you are taking this medicine.

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