Vitamin B Complex & C+ 20% Fat Emulsion

• Source of calories, essential fatty acids and water-soluble vitamins for patients requiring parenteral nutrition
• Preoperative and postoperative nutritional disturbances
• Burns
• Prolonged unconsciousness
• Cachexia
• Essential fatty acid deficiency

Adult Dose (IV):

• Initial infusion rate is 1ml/min for the first 15 to 30 mins. If no adverse reactions occur, the infusion rate can be increased to 2 ml/min. Do not exceed a daily dosage of 2.5 g/kg.

Child Dose (IV):

• Initial infusion rate is 0.1ml/min for the first 10 to 15 mins. If no adverse reactions occur, the infusion rate can be increased to 1g/kg in 4 hours. Do not exceed a daily dosage of 3 g/kg.

Infant Dose (IV):

• Starts at 0.5g/kg/24 hours and may be increased in relation to the infant's ability to eliminate fat. The maximum recommended dosage is 3g/kg/24 hours.

• As a part of TPN, administer IV via a peripheral vein or by central venous catheter
• Vidalin F IV should comprise no more than 60% of the patient's total caloric intake, with carbohydrates and amino acids comprising the remaining 40% or more of caloric intake
• Instructions for Use: Take 10 ml emulsion from 250 ml glass bottle by syringe; Open the cap of 10 ml vial and inject the syringe containing 10 ml emulsion into the vial; Take the emulsion from vial into syringe; Inject the syringe containing emulsion into the 250 ml glass bottle; Now give intravenously at 10 drops/ minute for the first 15 minutes and the rest at 20 drops/minute

Common Side Effects:

• Rise in body temperature (incidence <3%)
• Shivering, chills and nausea/vomiting (incidence <1%)
• Hypersensitivity reactions (anaphylactic reaction, skin rash, urticaria)
• Respiratory symptoms (tachypnoea)
• Circulatory effects (hypertension, hypotension)
• Thrombosis, haemolysis, reticulocytosis, abdominal pain, tiredness, priapism and neurological adverse reactions

• Contains soya oil and egg lecithin which may rarely cause allergic reactions
• Cross allergic reaction has been observed between soya-bean and peanut
• Fat metabolism may be disturbed in conditions such as renal insufficiency, uncompensated diabetes, pancreatitis, certain forms of liver insufficiency, metabolic disorders and sepsis
• Should be administered with caution as a strong correlation exists between C-reactive protein and the agglutination of Fat Emulsion and Water-soluble vitamin combination in seriously ill patients
• Should be given with caution to neonates and premature infants with hyperbilirubinemia and in cases with suspected pulmonary hypertension

• Contraindicated in conditions with severely disordered fat metabolism, such as in severe liver damage and acute shock
• Hypersensitivity to egg-, soya- or peanut protein or to any of active substances or excipients

• Insulin: may interfere with the body's lipase system; limited clinical importance
• Heparin: in clinical doses cause a transient increase in lipolysis in plasma, resulting in a transient decrease in triglyceride clearance
• Vitamin B6: can reduce the effect of Levodopa
• Folic Acid: may lower the serum concentration of Phenytoin

Use in Pregnancy: Absolute safety of the fetus and the nursing infant has not been established. Therefore, should be administered with caution during pregnancy.

Use in Lactation: Absolute safety of the fetus and the nursing infant has not been established. Therefore, should be administered with caution during lactation.

Renal Impairment: Administer with caution

Hepatic Impairment: Administer with caution

Symptoms: Fat overload syndrome (bone marrow depression, anemia, thrombocytopenia, hepatosplenomegaly, splenomegaly, hyperlipemia, fever, fat infiltration, focal seizures and shock).

Treatment: Discontinue infusion; symptoms are usually reversible.