Generic
Vitamin B1 + Vitamin B6 + Vitamin B12
135 brands available in the market
At a glance
This combination is indicated where a deficiency of the relevant vitamins exists. It is indicated for the treatment of polyneuropathy, neuritis, neuralgia, cervical syndrome, shoulder-arm syndrome, lumbago, sciatica, myalgia, intercostal neuralgia, herpes zoster, trigeminal neuralgia, supportive treatment in facial paresis.
Description
Vitamin B1 (Thiamine), B6 (Pyridoxine) & B12 (Cyanocobalamin). These vitamins play essential role as co-enzyme for the metabolism of nervous system. Thus this combination normalizes the nerve cell metabolism.
Indications
- B1, B6 and B12 deficiency syndrome
- Sciatica
- Lumbago
- Trigeminal neuralgia
- Facial paralysis
- Optic neuritis
- Diabetic neuropathy
- Peripheral neuralgia
- Myalgia
Therapeutic class
Specific combined vitamin preparations
Pharmacological class
Vitamins & Minerals
Pharmacology
Vitamin B1 (Thiamine), B6 (Pyridoxine) & B12 (Cyanocobalamin). These vitamins play essential role as co-enzyme for the metabolism of nervous system. Thus this combination normalizes the nerve cell metabolism.
Mechanism of action
Vitamins B1, B6, and B12 support normal nervous system function and red blood cell production.
Dosage
Adult Dose (Oral):
- 1-2 tablets three times daily
Adult Dose (IM):
- In severe cases: 1 injection daily until the acute symptoms subside
- For milder cases: 2 or 3 injections should be administered weekly
Administration
- Take as directed by a physician
- Swallow tablets whole
- Ampoules are preferably injected intramuscularly
Missed dose
If you miss a dose, take it as soon as you remember; if almost time for next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Generally well tolerated
- However, a few allergic reactions may be seen
Precautions & warnings
- Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord
- Cyanocobalamin is not a suitable form of Vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin
Contraindications
- Should not be used in the patients on Levodopa therapy
- Hypersensitivity to any of the active ingredients
Drug interactions
- No drug interaction has been reported yet
Food interactions
Food interactions are not significant.
Use in pregnancy
Use in Pregnancy: Oral tablet form is recommended; but due to the presence of benzyl alcohol, injection is not recommended during pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Oral tablet form is recommended; but due to the presence of benzyl alcohol, injection is not recommended during lactation.
Pediatric use
There is no information on the use of this drug in children
Geriatric use
Safe for elderly
Renal / hepatic impairment
Renal Impairment: Limited information
Hepatic Impairment: Limited information
Overdose effects
Symptoms: No overdosage symptoms are to be expected in the recommended dosage.
Treatment: Symptomatic & supportive.
Storage conditions
Keep out of reach of children. Store in a cool (below 25°C temperature) and dry place, protected from light.