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At a glance

Mifepristone + Misoprostol is a combination medicine used for medical termination of pregnancy.

Indications
  • Medical termination of pregnancy (up to 9 weeks)
  • Menstrual Regulation (MR)
Pharmacology

Mifepristone binds to progesterone receptor blocking progesterone action. Misoprostol acts through prostaglandin receptors causing uterine contractions.

Dosage

Adult Dose:

  • Day 1: Mifepristone 200 mg (1 tablet) single oral dose
  • Day 2 (24-48 hours later): Misoprostol 800 mcg (4 tablets) buccally or sublingually
  • Day 10-14: Follow-up visit
Side effects

Common Side Effects:

  • Nausea and vomiting
  • Diarrhea
  • Abdominal cramping
  • Uterine contractions
  • Vaginal bleeding
  • Dizziness
Use in pregnancy

Use in Pregnancy: Highly unsafe. Contraindicated during pregnancy.

Pregnancy Category: X — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Do not use if suspected ectopic pregnancy
  • Contraindicated in adrenal failure
  • Remove IUD before treatment
  • Caution in bleeding disorders
  • Contraindicated in pregnancy and lactation
Overdose effects

Mifepristone overdose may cause signs of adrenal failure. Misoprostol overdose may cause sedation tremor convulsions diarrhea fever.

Storage conditions

Store in a cool and dry place protected from light.

Mifepristone + Misoprostol — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.