৳ 825/unit
Pack: ৳ 825
৳ 825/unit
Pack: ৳ 825
At a glance
Insulin Aspart is a rapid-acting human insulin analog used to improve glycemic control in adults and children with diabetes mellitus.
Indications
- Improvement of glycemic control in adults and children with diabetes mellitus
Pharmacology
The primary activity of Insulin Aspart is the regulation of glucose metabolism. It binds to insulin receptors on muscle and fat cells, facilitating cellular glucose uptake and simultaneously inhibiting glucose output from the liver. It is homologous with regular human insulin except for a single substitution of proline by aspartic acid at position B28, which ensures rapid absorption and faster onset of action.
Dosage
Adult Dose (Subcutaneous):
- Type 1 Diabetes: 0.2-0.6 units/kg/day in divided doses; maintenance: 0.5-1 unit/kg/day; nonobese: 0.4-0.6; obese: 0.6-1.2
- Type 2 Diabetes: Initial: 0.2-0.4 units/kg/day q8hr-q12hr; with intermediate (NPH) or long-acting insulin at bedtime
- 50-75% of insulin requirements provided by intermediate- or long-acting insulin; remainder as rapid-acting insulin before or at mealtimes
Child Dose (Type 1, >2 years): 0.5-1 unit/kg/day; adolescents <1.2 units/kg/day
Side effects
Side Effects:
- Hypoglycemia
- Injection site reactions (redness, swelling, pain)
- Lipodystrophy
- Pruritus
- Rash
- Allergic reactions
Use in pregnancy
Use in Pregnancy: Category B; generally considered safe; animal studies show low or no adverse effects; limited human studies.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Hypoglycemia is a common side effect; monitor blood sugar regularly
- Always carry sugary food or fruit juice for hypoglycemia symptoms (cold sweats, pale skin, tremors, weakness, anxiety)
- Rotate injection sites (to prevent lipodystrophy)
- Opened vials/cartridges stay good at room temperature for up to 4 weeks; unopened vials must be refrigerated (2°C-8°C)
- Do not use if preparation is no longer clear and colorless or contains particles
- Caution in renal and hepatic impairment (dose adjustment may be needed)
Overdose effects
Overdose: No specific overdose definition for insulin; hypoglycemia may develop; mild episodes treated with oral glucose or sugary products; severe episodes with glucagon (0.5-1 mg) IM/SC or IV glucose; oral carbohydrate recommended after regaining consciousness.
Storage conditions
Store at 2°C to 8°C in refrigerator; do not freeze; protect from light.