Actomeg 850

Metformin Hydrochloride + Pioglitazone is a combination medicine that helps control blood sugar levels. This medicine is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It helps in proper utilisation of insulin, thereby lowering the blood sugar level. Metformin Hydrochloride + Pioglitazone should be taken in the dose and duration as advised by your doctor. It must be taken with food to avoid stomach upset. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Overdose may lead to low blood sugar (hypoglycemia). Some people may develop common side effects like nausea, loss of appetite, taste changes, stomach pain, diarrhea, edema (swelling) and blurred vision. However, these are usually not bothersome. If these do not resolve or worry you, please consult your doctor. Before taking this medicine, inform your doctor if you have any kidney, liver or heart problems. Pregnant or breastfeeding women should also consult their doctor before taking it. Your doctor will check your kidney function tests before starting treatment with it. Avoid excessive alcohol intake while taking it as this may increase the risk of developing some side effects. Metformin Hydrochloride + Pioglitazone is a combination of two antidiabetic medicines: Pioglitazone and metformin. Pioglitazone is a thiazolidinedione which works by increasing the body's sensitivity to insulin. Metformin is a biguanide which decreases the production and absorption of sugar in your body and allows better use of existing insulin. Together, they provide better control of blood sugar.

• Type 2 diabetes mellitus

Pioglitazone is as a potent and highly selective agonist for the peroxisome proliferator activated receptor-gamma. Activation of these receptors promotes the production of gene products involved in lipid and glucose metabolism. It also improves insulin response to target cells witho increasing the pancreatic secretion of insulin. Metformin decreases hepatic gluconeogenesis, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilisation).

Adult Dose: Oral Type 2 diabetes mellitus Adult: Tab contains pioglitazone 15 mg and metformin 500 mg or 850 mg: Initially, 15 mg/500 mg bid or 15 mg/850 mg once daily. Patients inadequately controlled on metformin monotherapy: Initially, 15 mg/500 mg bid or 15 mg/850 mg 1-2 times daily, depending on current metformin dose. Patients inadequately controlled on pioglitazone monotherapy: Initially, 15 mg/500 mg bid or 15 mg/850 mg once daily. Max: Pioglitazone 45 mg and metformin 2,550 mg daily. Hepatic impairment: Contraindicated. Child Dose: Safety and efficacy not established Renal Dose: Renal impairment Obtain eGFR before starting metformin eGFR <30 mL/min/1.73 m²: Contraindicated eGFR 30-45 mL/min/1.73 m²: Not recommended to initiate treatment Monitor eGFR at least annually or more often for those at risk for renal impairment (eg, elderly) If eGFR falls below 45mL/min/1.73 m² while taking metformin, risks and benefits of continuing therapy should be evaluated If eGFR falls below 30 mL/min/1.73 m²: while taking metformin, discontinue the drug

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metformin Hydrochloride + Pioglitazone is to be taken with food.

Common: • Nausea • Loss of appetite • Taste change • Stomach pain • Diarrhea • Edema (swelling) • Weight gain • Respiratory tract infection • Bone fracture • Blurred vision

[CAUTION] Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur. Take it as per the dose and duration prescribed by your doctor. Monitor your blood sugar level regularly while you are taking this medicine. It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety. Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice). Inform your doctor if you notice weight gain, shortness of breath, irregular heartbeat, or any abnormal swelling.

Renal disease or renal dysfunction (e.g. as suggested by serum creatinine levels >1.5 mg/dl in male, >1.4 mg/dl in females or abnormal creatinine clearance), which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction and septicemia.Current or history of cardiac failure, active or history of bladder cancer, Known hypersensitivity to Pioglitazone, Metformin or any other component of this combination. Acute or chronic metabolic acidosis including diabetic ketoacidosis with or without coma.

Additive effect w/ sulfonylureas. Thiazide diuretics, corticosteroids, phenothiazines, OC, sympathomimetics, niacin, Ca channel blockers and isoniazid may exacerbate loss of glycaemic control. ACE inhibitors may reduce fasting blood glucose concentrations. May increase serum level w/ cimetidine. Potentially Fatal: Concurrent use w/ iodinated contrast agents may increase the risk of metformin-induced lactic acidosis.

[UNSAFE] It is unsafe to consume alcohol with Metformin Hydrochloride + Pioglitazone.

[CONSULT YOUR DOCTOR] Metformin Hydrochloride + Pioglitazone may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Metformin Hydrochloride + Pioglitazone is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Metformin Hydrochloride + Pioglitazone should be used with caution in patients with kidney disease. Dose adjustment of Metformin Hydrochloride + Pioglitazone may be needed. Please consult your doctor. Use of Metformin Hydrochloride + Pioglitazone is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine. [CAUTION] Metformin Hydrochloride + Pioglitazone should be used with caution in patients with liver disease. Dose adjustment of Metformin Hydrochloride + Pioglitazone may be needed. Please consult your doctor. Metformin Hydrochloride + Pioglitazone is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.

Take Pioz MF 7.5 twice ,was substuted by Dr. Online one time by Riomet Duo 1 Needs sugar level variation chart for suggesting the dosage of medicine. I have type 2 diabetes from last 3year.still last 3 year I haven&#x27;t gain weights(60kg) Glizid M 80/500 and pioz mf 7.5 this are the present medicine of mine, Hba1c is 7.7.what should I do to gain weight reasons for not gaining your weight2. your are taking metformin which itself causes weight loss besides its antidiabetic benefits I am taking Pioz MF 7.5, since it is said to be banned, prescribe me a substitute It is not good control.A person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND LOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you souls not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET my sugar level is after lunch 200 to 250 and evening go down up to 50 to 55 dose 1/2 tab volixm-3 before breakfast 1/2 volix m-3 before lunch 1/2 pioz mf-15 please advise Need to personally examine and see all reports and advise accordingly We heard that this combination is banned. What is the alternate medicine.i take 1 tab moring pioz mf 15/500 and evening metformin 500 mg. Sugar level ok Pl suggest alternate drug Need to make some change in dose consult doctor near by as online prescription not allowed Diabetes mellitus type 2 ,thirst A person can control his or her sugar levels by doing regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOUR DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you should not treat it as disease but a start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications like kidney or heart problems .online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET I am diabetic since 10 years and at present I got on random checking 200. I take Glycomet GP2 post breakfast and dinner and Pioz MF 15 in the afternoon after lunch.My blood pressure comes around 200. get Blood sugar F and PP, HbA1c and BP checked by a Doctor