৳ 5/unit
Pack: ৳ 5
৳ 5/unit
Pack: ৳ 5
At a glance
Doxepin is a tricyclic antidepressant used for the treatment of insomnia, depression and anxiety disorders. It works by increasing levels of chemical messengers in the brain that stabilize and enhance mood.
Indications
- Insomnia
- Depression
- Anxiety
Pharmacology
Doxepin is a potent histamine H1- and H2-receptor antagonist. It inhibits serotonin and norepinephrine re-uptake, increasing their synaptic concentration in the CNS.
Dosage
Adult Dose: Depression/Anxiety: 25 mg/day start, gradually titrate upward; range 25-300 mg/day. Insomnia (Silenor): 3-6 mg within 30 minutes before bedtime; max 6 mg/day.
Elderly Dose: Insomnia: 3 mg before bedtime, may increase to 6 mg. Depression/Anxiety: 10 mg/day start, gradually adjust.
Side effects
Common Side Effects:
- Constipation
- Difficulty in urination
- Dryness in mouth
- Increased heart rate
- Orthostatic hypotension
- Weight gain
Use in pregnancy
Doxepin may be unsafe during pregnancy. Animal studies have shown harmful effects. Doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Helps treat insomnia, depression and anxiety.
- Inform doctor of behavioral changes, mood changes and suicidal thoughts.
- Regular blood tests may be needed to monitor blood cell count or sodium and sugar levels.
- Do not drive or do anything that requires concentration until you know how the medicine affects you.
Overdose effects
Overdose may cause suicidal thoughts, confusion, loss of consciousness, seizures, heart problems. Seek emergency medical attention.
Storage conditions
Store in a cool and dry place, away from light. Keep out of reach of children.