৳ 27
৳ 2.70 /unit
৳ 27
৳ 2.70 /unit
At a glance
Cetirizine Hydrochloride is a potent antihistamine used for the relief of symptoms associated with seasonal and perennial allergic rhinitis and chronic idiopathic urticaria.
Indications
Allergic rhinitis (seasonal and perennial) symptoms (sneezing, rhinorrhea, itchy/red eyes), uncomplicated skin manifestations of chronic idiopathic urticaria, allergen-induced asthma.
Pharmacology
Cetirizine Hydrochloride is a potent H1 receptor antagonist that inhibits the histamine-mediated early phase of allergic reactions and reduces the migration of inflammatory cells and the release of mediators associated with the late phase of allergic reactions. At pharmacologically active doses, it causes almost no drowsiness and does not cause behavioral changes. Food does not affect the extent of absorption but may slightly reduce the rate. Plasma half-life is approximately 11 hours.
Dosage
Oral Dosage:
- Adults and children ≥6 years: 1 tablet or 2 teaspoonfuls daily (or 1 teaspoonful twice daily)
- Children 2-6 years: 1 teaspoonful once daily or 1/2 teaspoonful twice daily
- Children 6 months-2 years: 1/2 teaspoonful once daily (12-23 months: up to 1/2 teaspoonful every 12 hours)
IV Injection (acute urticaria):
- Adults and adolescents ≥12 years: 10 mg IV push (over 1-2 minutes)
- Children 6-11 years: 5-10 mg IV push
- Children 6 months-5 years: 2.5 mg IV push
Side effects
Most common side effect: Somnolence (drowsiness)
Other side effects: Headache, dry mouth, dizziness, fatigue.
Use in pregnancy
Pregnancy Category: B. No adequate and well-controlled studies in pregnant women. Use only if clearly needed.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Caution should be exercised when driving or operating heavy machinery due to potential drowsiness. Alcohol or other CNS depressants may increase drowsiness.
Overdose effects
Overdose may result in significant somnolence. Manage with standard supportive measures and gastric decontamination if necessary.
Storage conditions
Store in a dry place away from light and heat. Keep out of reach of children.