Amaryl M 1

• Type 2 diabetes mellitus - as an adjunct to diet and exercise
• When monotherapy with glimepiride or metformin does not result in adequate glycemic control
• Replacement of combination therapy of glimepiride and metformin

Glimepiride is a sulfonylurea antidiabetic agent which decreases blood glucose concentration. The primary mechanism of action appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. Metformin Hydrochloride is a biguanide type oral antihyperglycemic drug used in the management of type 2 diabetes. It lowers both basal and postprandial plasma glucose. Metformin Hydrochloride decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity by an increase in peripheral glucose uptake and utilization.

Adult Dose:

• Each tablet contains glimepiride 1 mg or 2 mg and metformin SR 500 mg
• Initial: One tablet once daily
• Maximum glimepiride: 8 mg daily
• Maximum metformin: 2000 mg daily

Children: Data is insufficient

* Use as directed by the registered physician

Common Side Effects:

• Hypoglycemia (low blood sugar)
• Taste change
• Nausea
• Diarrhea
• Stomach pain
• Headache
• Upper respiratory tract infection

Use in Pregnancy: May be unsafe during pregnancy. Animal studies have shown harmful effects.

Precautions:

• Hypoglycemia may occur when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
• Avoid alcohol (increases hypoglycemia risk).
• Inform doctor if you experience deep or rapid breathing, persistent nausea, vomiting, or stomach pain (signs of lactic acidosis).
• Regular kidney and liver function tests recommended.
• Not recommended in severe kidney disease.

Overdose: Hypoglycemia from glimepiride. Lactic acidosis from metformin. Gastric lavage, activated charcoal and supportive care. Hemodialysis is effective.

Storage: Store below 25°C in a cool and dry place, protected from light. Keep out of reach of children.