৳ 10/unit
Pack: ৳ 100
৳ 10/unit
Pack: ৳ 100
At a glance
Donepezil Hydrochloride is a centrally-acting anticholinesterase agent used for the symptomatic treatment of mild to moderate dementia of Alzheimer's type.
Indications
- Mild to moderate dementia of Alzheimer's type
Pharmacology
Donepezil Hydrochloride is a centrally acting anticholinesterase agent. It binds reversibly with acetylcholinesterase and inactivates it, thus inhibiting hydrolysis of acetylcholine. As a result the concentration of acetylcholine increases at cholinergic synapses in the brain.
Dosage
Adults and Elderly: Initially 5 mg once daily at bedtime; increase to 10 mg once daily after 4-6 weeks if needed.
Hepatic/Renal impairment: Similar dose schedule can be followed.
Side effects
Common: Nausea, vomiting, diarrhea.
Other: Insomnia, fatigue, anorexia, muscle cramps, generalized seizure.
Use in pregnancy
Pregnancy Category C. Donepezil may be unsafe during pregnancy. Animal studies have shown harmful effects on the developing baby.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
May affect driving ability (drowsiness, dizziness, blurred vision). Caution in sick sinus syndrome, risk of peptic ulcers, asthma, obstructive airway disease. Caution in peptic ulcer (may cause vomiting, stomach bleeding).
Overdose effects
Overdose may cause nausea, vomiting, salivation; very high doses may cause cholinergic crisis (severe nausea, bradycardia, hypotension, muscle weakness, respiratory depression, collapse, convulsions). Hospitalization is required.
Storage conditions
Keep below 30°C temperature, away from light & moisture.