৳ 170
৳ 17 /unit
৳ 170
৳ 17 /unit
At a glance
Naproxen + Esomeprazole is a combination tablet containing Naproxen, a Non-Steroidal Anti-inflammatory Drug (NSAID), and Esomeprazole, a Proton Pump Inhibitor (PPI). It is primarily used to relieve pain, inflammation, and joint stiffness associated with Osteoarthritis, Rheumatoid Arthritis, and Ankylosing Spondylitis while reducing the risk of NSAID-associated gastric ulcers. The tablet should generally be taken at least 30 minutes before meals. It is a prescription medicine and should only be used under the supervision of a registered healthcare professional. The medicine is contraindicated during the third trimester of pregnancy and is generally not recommended during breastfeeding. Store below 30°C in a dry place away from light and moisture.
Indications
This medicine is indicated for: Relief of signs and symptoms of Osteoarthritis. Management of Rheumatoid Arthritis. Treatment of Ankylosing Spondylitis. Reducing the risk of NSAID-associated gastric ulcers. Providing gastric protection in patients requiring long-term NSAID therapy.
Pharmacology
This tablet is specially formulated so that Esomeprazole is released first in the stomach to suppress gastric acid secretion. The enteric-coated Naproxen core then dissolves in the small intestine, providing anti-inflammatory and analgesic effects while minimizing gastric irritation. This formulation helps reduce the gastrointestinal risks commonly associated with long-term NSAID therapy.
Dosage
The dosage of Naproxen + Esomeprazole Tablet should be individualized according to the patient's age, clinical condition, disease severity, and treatment response. The lowest effective dose should be used for the shortest duration necessary. Adults: One tablet of either 375 mg Naproxen/20 mg Esomeprazole or 500 mg Naproxen/20 mg Esomeprazole twice daily for Osteoarthritis, Rheumatoid Arthritis, and Ankylosing Spondylitis. Adolescents (12 years and older): Body weight over 50 kg: 375/20 mg or 500/20 mg twice daily. Body weight 38–50 kg: 375/20 mg twice daily. Do not change the prescribed dose without consulting your physician.
Side effects
Most patients tolerate this medicine well, but some side effects may occur. Common Side Effects Nausea Vomiting Abdominal pain Indigestion Heartburn Diarrhea Constipation Flatulence Headache Dizziness Serious Side Effects Gastric ulcer Gastrointestinal bleeding Black stools Vomiting blood Hypertension Fluid retention Kidney impairment Severe allergic reactions Increased risk of heart attack or stroke Seek immediate medical attention if any serious symptoms develop.
Use in pregnancy
Naproxen + Esomeprazole Tablet should be used during pregnancy only if clearly recommended by a physician. In women who are planning to become pregnant or are in the first or second trimester, the medicine should be prescribed only when the expected benefit outweighs the potential risk to the fetus. This medicine is contraindicated during the third trimester of pregnancy, as it may adversely affect fetal development and interfere with normal labor and delivery. Pregnant women should never use this medicine without medical supervision.
Precautions & warnings
Inform your healthcare provider about your complete medical history before starting treatment. Use with caution in patients with: History of stomach ulcers Hypertension or cardiovascular disease Kidney or liver impairment Use of anticoagulants Long-term NSAID therapy Elderly age (over 65 years) Regular medical monitoring is recommended during prolonged treatment.
Overdose effects
An overdose may cause drowsiness, dizziness, severe abdominal pain, nausea, vomiting, gastrointestinal bleeding, breathing difficulty, kidney dysfunction, confusion, or even coma in severe cases. If an overdose is suspected, seek immediate medical attention. There is no specific antidote for Naproxen + Esomeprazole overdose, and treatment is mainly supportive and symptomatic.
Storage conditions
Store below 30°C. Protect from light and moisture. Keep the medicine in its original packaging. Keep out of the reach of children. Do not use the medicine after the expiry date.