Aprila30mg
Rx- Generic:
- Apremilast
- Company:
- Drug International Ltd.
- Dosage form:
- Tablet
- Pack size:
- Tablet
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৳ 60/unit
Pack: ৳ 60
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At a glance
Apremilast is a phosphodiesterase 4 (PDE4) inhibitor used for the treatment of moderate to severe plaque psoriasis and active psoriatic arthritis in adult patients who are candidates for phototherapy or systemic therapy.
Indications
- Active psoriatic arthritis
- Moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy
Dosage
Recommended Dose Titration (to reduce GI symptoms):
| Day | Morning | Evening |
|---|---|---|
| Day 1 | 10 mg | — |
| Day 2 | 10 mg | 10 mg |
| Day 3 | 10 mg | 20 mg |
| Day 4 | 20 mg | 20 mg |
| Day 5 | 20 mg | 30 mg |
| Day 6 and onwards | 30 mg | 30 mg |
Maintenance Dose: 30 mg twice daily from Day 6
Severe Renal Impairment (CrCl <30 mL/min): Reduce dose to 30 mg once daily. Use only morning schedule; skip evening doses.
Hepatic Impairment: No dosage adjustment required.
Side effects
Common (>10%):
- Nausea
- Diarrhea
- Headache
Other (1-10%):
- Upper respiratory tract infection
- Vomiting
- Nasopharyngitis
- Abdominal pain
- Hypersensitivity
- Gastroesophageal reflux disease
- Dyspepsia
- Fatigue
- Decreased appetite
- Cough
- Rash
- Insomnia
Weight Loss: 5-10% body weight loss reported during treatment.
Precautions & warnings
Serious Precautions:
- Inform your doctor immediately if you experience new or worsened depression, suicidal thoughts, or other mood changes
- Monitor weight regularly - apremilast may cause weight loss
- Caution during pregnancy - animal studies have shown harmful effects on the developing baby
- Caution during breastfeeding - apremilast was detected in milk of lactating mice
- Dose adjustment needed in severe renal impairment
- Mild stomach upset may occur early during treatment but usually resolves
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.