৳ 15/unit
Pack: ৳ 90
৳ 15/unit
Pack: ৳ 90
At a glance
Itraconazole is an antifungal medication used for the treatment of fungal infections of the mouth, throat, vagina, skin, and nails.
Indications
- Oropharyngeal candidiasis
- Vulvovaginal candidiasis
- Pityriasis versicolor
- Tinea pedis, tinea cruris, tinea corporis, tinea manuum
- Onychomycosis (fungal nail infections)
- Histoplasmosis
- Systemic candidiasis
- Aspergillosis
- Cryptococcosis
Pharmacology
Itraconazole inhibits Cytochrome P-450 dependent enzymes resulting in impairment of ergosterol biosynthesis, a major component of the cell membrane of yeast and fungal cells. Being integral to proper functioning of the cell membrane, inhibition of ergosterol synthesis leads to abnormalities in permeability, membrane bound enzyme activity, and coordination of chitin synthesis, leading to inhibition of growth, abnormal cell wall formation and accumulation of intracellular lipids and membranous vesicles.
Dosage
Adult Dose (Oral):
- Vulvovaginal candidiasis: 200 mg twice daily × 1 day
- Pityriasis versicolor: 200 mg once daily × 7 days
- Tinea corporis/cruris: 100 mg once daily × 15 days or 200 mg once daily × 7 days
- Tinea pedis/manuum: 100 mg once daily × 30 days
- Oropharyngeal candidiasis: 100 mg once daily × 15 days
- Onychomycosis: 200 mg once daily × 3 months or pulse therapy: 200 mg twice daily × 7 days, 21 days off, repeat
- Systemic fungal infections: 100-200 mg once daily; invasive/disseminated: 200 mg twice daily
Child Dose (Oral):
- 10 mg/kg/day (max 200 mg/day) q12h; 5 mg/kg/day q24h for chronic mucocutaneous Candida
- <3 years: Safety and efficacy not established
Side effects
Common Side Effects:
- Nausea
- Abdominal pain
- Dyspepsia
- Constipation
- Headache
- Dizziness
- Raised liver enzymes
- Menstrual disorders
Others: Allergic reactions (pruritus, rash, urticaria, angioedema), hepatitis and cholestatic jaundice, peripheral neuropathy, Stevens-Johnson syndrome, hypokalemia, edema, hair loss (with prolonged use)
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; contraindicated in pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Itraconazole may affect your ability to drive (dizziness, blurred/double vision, hearing loss)
- Absorption is impaired when gastric acidity is reduced; take antacids 2 hours after Itraconazole
- Take after a full meal
- Monitor liver function regularly (treatment >1 month)
- Inform doctor if signs of jaundice (yellowing of eyes or skin, dark urine, stomach pain)
- Contraindicated in pregnancy and lactation
Overdose effects
Overdose: No experience of overdosage; if accidental overdose occurs, gastric lavage and symptomatic treatment; no specific antidote.
Storage conditions
Store below 25°C, in a cool & dry place; keep away from light; keep out of reach of children.