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At a glance

Neomycin Sulfate + Bacitracin Zinc + Polymyxin B Sulfate is a combination topical antibiotic ointment used for infected wounds, burns, skin grafts, furuncles, carbuncles, pyoderma, impetigo and acne.

Indications
  • Infected wounds
  • Burns
  • Skin grafts
  • Donor site preparation
  • Chronic varicose or indolent ulcers
  • Furuncles, carbuncles
  • Pyoderma, sycosis barbae
  • Impetigo, acne
  • Secondary infected skin lesions of scabies, pediculosis, tinea pedis
Pharmacology

Polymyxin B sulfate interacts with phospholipid components of bacterial cell membrane to produce bactericidal effect. Neomycin binds to 30S ribosomal subunit to inhibit protein synthesis. Bacitracin zinc inhibits bacterial cell wall synthesis.

Dosage

Adult Dose (Topical):

  • Apply a thin layer to affected area 1-3 times daily
  • Continue until infection is controlled and healing complete

Pediatric Dose: Same as adults; however, not recommended for neonates

Side effects

Side Effects:

  • Nausea, vomiting
  • Pain, burning or swelling
  • Skin rashes
  • Kidney problems
  • Hearing loss
  • Dizziness
  • Unusual numbness of skin
  • Muscle twitching
  • Seizures
Use in pregnancy

Use in Pregnancy: Little information on topical neomycin in pregnancy; not recommended in pregnancy.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Not intended for sterile use in surgical procedures (may potentiate neuromuscular block)
  • Prolonged use may result in overgrowth of non-susceptible organisms
  • Enhanced absorption in neonates and infants with immature renal function
Overdose effects

Overdose unlikely (topical use); symptomatic treatment.

Storage conditions

Store below 30°C; keep out of reach of children.

Neomycin Sulfate + Bacitracin Zinc + Polymyxin B Sulfate — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.