Bisoren Plus 5
Rx- Generic:
- Bisoprolol + Hydrochlorothiazide
- Company:
- Renata Limited
- Dosage form:
- Tablet
- Pack size:
- Strip (10 Tablet)
৳ 11.50/unit
Pack: ৳ 115
At a glance
Bisoprolol + Hydrochlorothiazide — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Bisoprolol + Hydrochlorothiazide is a medicine used to treat hypertension (high blood pressure). Bisoprolol + Hydrochlorothiazide is a combination of two medicines that helps to control blood pressure when a single medication is not effective. It helps to reduce chances of any future heart attack and stroke. Bisoprolol + Hydrochlorothiazide is taken with or without food preferably in the morning to avoid frequent urination at night. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it, your condition may get worse. Keeping active with regular exercise, reducing your weight and eating a healthy diet will also help control your blood pressure. Follow your doctor's advice while taking this medicine. Nausea, constipation, diarrhea, and fatigue are some common side effects of this medicine. Consult your doctor If any of these bother you, or get worse, or Do not go away. Drink plenty of fluids while taking medicine to overcome muscle weakness, dry mouth and extreme thirst. Dizziness or headache may occur due to low blood pressure but this gets better with time. Before taking it, let your doctor know if you have any liver or kidney problems. Pregnant or breastfeeding women should also consult their doctor for advice before taking this medicine. You also need to tell your doctor what other medicines you are taking especially those used to treat high blood pressure or heart conditions. You should have your blood pressure, kidney function, blood sugar level and the levels of salts such as potassium or magnesium checked regularly to make sure that this medicine is working properly. Bisoprolol + Hydrochlorothiazide is a combination of two blood-pressure lowering medicines: Bisoprolol and Hydrochlorothiazide. Bisoprolol is a beta blocker. It works specifically on the heart to improve its efficiency of pumping blood throughout the body. Hydrochlorothiazide is a diuretic which lowers blood pressure by removing extra water from the body. Over time it also relaxes blood vessels and improves blood flow.
Indications
• Hypertension (high blood pressure)
Mechanism of action
Bisoprolol fumarate/hydrochlorothiazide is a fixed-combination tablet that combines a Beta adrenergic receptor blocker, bisoprolol fumarate, and a thiazide diuretic, hydrochlorothiazide. Bisoprolol fumarate, a cardioselective inhibitor of beta(1)-adrenoceptor, has no significant intrinsic sympathomimetic activity or membrane stabilizing activity in its therapeutic dosage; exhibits beta(2)-adrenoceptors inhibition and negative chronotropic effect. Hydrochlorothiazide is a thiazide diuretic that inhibits Na reabsorption in distal renal tubules resulting in increased excretion of Na+ and water, also K+ and H+ ions.
Dosage
Adult Dose: Adult: PO Initial: 2.5 mg/6.25 mg tablet once daily. Increase based on clinical response in 2 weeks, Maximum: bisoprolol 20 mg/hydrochlorothiazide 12.5 mg once daily. Elderly: Dosage adjustment for geriatric patients usually not necessary Renal Dose: Renal Impairment Use caution in dosing/titrating patients with renal dysfunction Cumulative effects of thiazides may develop with impaired renal function CrCl <40mL/min: half-life of bisoprolol fumarate is increased up to threefold
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bisoprolol + Hydrochlorothiazide may be taken with or without food, but it is better to take it at a fixed time.
Side effects
Common: • Nausea • Constipation • Fatigue • Headache • Diarrhea • Dizziness • Cold extremities • Slow heart rate • Increased blood uric acid • Decreased potassium level in blood • Glucose intolerance • Altered blood lipid level • Decreased magnesium level in blood • Increased calcium level in blood
Precautions & warnings
[CONSULT YOUR DOCTOR] It is not known whether Bisoprolol + Hydrochlorothiazide alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. It is a combination of two blood pressure lowering medications used for the treatment of high blood pressure. It can be taken with or without food. Do not stop taking Bisoprolol + Hydrochlorothiazide suddenly as it can cause your blood pressure to rise suddenly thereby increasing the risk of heart attack and stroke. It may cause dizziness. If this happens to you, get up slowly when rising from a sitting or lying position. It can hide symptoms of low blood sugar if you're diabetic. Monitor your blood sugar levels regularly. Bisoprolol + Hydrochlorothiazide may cause dehydration. Drink plenty of fluids and Inform your doctor if you develop extreme thirst, muscle weakness or very dry mouth.
Contraindications
Low cardiac output and uncompensated cardiac failure; sinus bradycardia, 1st ° heart block, cardiogenic shock, bronchospasm; severe haemorrhage. Pregnancy.
Drug interactions
Bisoprolol : May potentiate AV conduction time and may increase negative inotropic effect w/ class I antiarrhythmic drugs (e.g. quinidine, disopyramide, propafenone). Concomitant catecholamine-depleting drugs (e.g. reserpine, guanethidine) may produce excessive sympathetic activity. May exacerbate rebound HTN upon discontinuance of clonidine treatment. Increased risk of bradycardia w/ digitalis glycosides. Reduced hypotensive effect w/ NSAIDs. Hydrochlorothiazide: Increases toxicity of lithium. May potentiate orthostatic hypotension w/ barbiturates and narcotics. Enhanced neuromuscular blocking action of competitive neuromuscular blockers (e.g. atracurium). Increased hypokalaemic effect w/ corticosteroids, corticotropin, ?2 agonists (e.g. salbutamol). Additive effect w/ other antihypertensives. Potentiation of orthostatic hypotension w/ barbiturates or opioids. Reduced antihypertensive effect by drugs that cause fluid retention (e.g. corticosteroids, NSAIDs, carbenoxolone). Enhanced nephrotoxicity of NSAIDs. Reduced therapeutic effect of antidiabetics.
Food interactions
[UNSAFE] Bisoprolol + Hydrochlorothiazide may cause excessive drowsiness with alcohol.
Use in pregnancy
[CONSULT YOUR DOCTOR] Bisoprolol + Hydrochlorothiazide may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Use in lactation
[CONSULT YOUR DOCTOR] Bisoprolol + Hydrochlorothiazide is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Renal / hepatic impairment
[CAUTION] Bisoprolol + Hydrochlorothiazide should be used with caution in patients with kidney disease. Dose adjustment of Bisoprolol + Hydrochlorothiazide may be needed. Please consult your doctor. Regular blood pressure monitoring is advisable for dose adjustment. [CAUTION] Bisoprolol + Hydrochlorothiazide should be used with caution in patients with liver disease. Dose adjustment of Bisoprolol + Hydrochlorothiazide may be needed. Please consult your doctor.
Common questions
Her blood pressure is190/95 without medicine. She is taking two tablets lodoz 2.5 mg every day. Now it's145/85 Her parameters of cholesterol etc are normal. Please advise. Antihypertensive may be continued to keep BP under control I am suffering from high blood pressure, earlier I used to take Lodoz 2 but now doctor changed to Envas 5 daily. Is there any solution? Take regular medicine n regular check ups , reduce salt intake n exercise well, eat healthy food. Reduce stress. I am a patient of hypertension Hypertension is clinal condition of high blood pressure. Please see a physician. Some times I had lot of hypertension Hypertension is clinically high blood pressure. Persistent high arterial blood pressure above 120/80 mm HG is termed as pre-hypertension or hypertension, but the point to be emphasized is that this rise in blood pressure is persistent. Transient increase in BP occurs in stress and anxiety and needs to be treated accordingly. Sir presently I m taking lodoz 2.5, unistar 75 and nexito plus. Can I take herbal medicine of curcumine and seacode capsule. And I also started one egg daily. Is there any harm. no idea about herbal better avoid things not standardised High blood pressure, breathing issues Do yoga and pranayam regularly, take halleezy tablet 2 tablet twice Hypertension blood pressure pro Bp any medicine u taking high blood pressure 160/90 and heart rate 130 I am already to taken tazloc-h 40mg Can change to besicor t 2.5/40 will control both rate and BP after consulting with your physician