Bugesic200mcg

Buprenorphine is used to treat moderate to severe pain and drug dependence/addiction to opioids. It helps to prevent withdrawal symptoms that may be caused due to withdrawal of other opioids. Buprenorphine is only prescribed to individuals who are at least 16 years of age or above. It may be habit forming and should be taken only as directed by your doctor. The medicine may be a part of your treatment which could include receiving social and psychological support. It can be taken with or without food. You should continue taking this medicine regularly until the doctor tells you it is alright to stop. Try not to miss doses as this will make the medicine less effective. Some common side effects of this medicine include weakness, drug withdrawal syndrome, anxiety, nervousness, dizziness, headache, sleepiness, diarrhea, nausea, vomiting, and abdominal pain. If any of these side effects do not resolve with time or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. To make it sure it is safe for you, before taking this medicine, let your doctor know if you have any medical conditions or disorders. You should also tell your doctor all the other medicines you are using or taking. Pregnant and breastfeeding women should consult their doctors before using this medicine. Buprenorphine is a opioid partial agonist. It prevents withdrawal symptoms in patients who stop taking opioid drugs by producing similar effects to these drugs.

• Opioid (Morphine) dependence

Buprenorphine exerts its analgesic effect by binding to the mu-opioid receptors in the CNS. It has a longer duration of analgesic action than morphine. Its partial agonist activity gives it a low level of physical dependence. Buprenorphine and morphine show similar dose-related resp depressant effect.

Adult Dose: Adult: Sublingual Moderate to severe pain 200-400 mcg 6-8 hrly. IV Perioperative analgesia 300-450 mcg via slow inj. IV/IM Moderate to severe pain 300-600 mcg 6-8 hrly. IM Anesth premed 300 mcg. Elderly: Moderate-to-Severe Pain 0.15 mg IV/IM q6hr; for IV, administered slowly over 2 minutes Child Dose: Moderate-to-Severe Pain 12 years: As in adults

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Buprenorphine may be taken with or without food, but it is better to take it at a fixed time.

Common: • Weakness • Drug withdrawal syndrome

[UNSAFE] Buprenorphine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Take it at the same time every day to help you remember to take it. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Use caution while driving or doing anything that requires concentration as Buprenorphine can cause dizziness and sleepiness. Avoid drinking alcohol or taking other medicines that can cause drowsiness. Discontinue the medicine and inform your doctor if you experience difficulty breathing. Do not stop taking Buprenorphine without talking to your doctor first as it may cause a worsening of symptoms. Your doctor may get regular blood tests to check for liver function while taking this medicine.

Acute alcoholism; convulsive disorders; head injuries; increased intracranial pressure; comatose patients; resp depression and obstructive airway disease; patients on established opioid agonists.

Plasma-buprenorphine concentrations may be affected when co-administered with drugs that induce or inhibit cytochrome P450 isoenzyme CYP3A4. Enhanced depressant effects with other CNS depressants e.g. alcohol, anaesthetics, anxiolytics, hypnotics, TCAs and antipsychotics. Potentially Fatal: Diazepam may produce resp and cardiac collapse.

[UNSAFE] It is unsafe to consume alcohol with Buprenorphine.

[CONSULT YOUR DOCTOR] Buprenorphine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Buprenorphine is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Buprenorphine should be used with caution in patients with severe kidney disease. Dose adjustment of Buprenorphine may be needed. Please consult your doctor. [CAUTION] Buprenorphine should be used with caution in patients with liver disease. Dose adjustment of Buprenorphine may be needed. Please consult your doctor. Use of Buprenorphine is not recommended in patients with serious liver disease.

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