৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Buprenorphine is a partial opioid agonist used in the treatment of moderate to severe pain and opioid dependence. It provides pain relief by binding to mu-opioid receptors in the CNS and helps prevent withdrawal symptoms in patients stopping other opioids.
Indications
- Moderate to severe pain
- Opioid dependence
Pharmacology
Buprenorphine is a partial opioid agonist that binds to mu-opioid receptors to relieve pain. Its partial agonist activity results in lower respiratory depression risk compared to full agonists. In opioid dependence, it replaces other opioids, reducing withdrawal symptoms and helping to eliminate dependence.
Dosage
Adults (Sublingual, Pain): 200-400 mcg every 6-8 hours.
Adults (IV/IM, Pain): 300-600 mcg every 6-8 hours.
Adults (Perioperative Analgesia, IV): 300-450 mcg slow IV injection.
Adults (Anesthesia Premed, IM): 300 mcg.
Elderly (Moderate-to-Severe Pain): 0.15 mg IV/IM q6hr (slow IV over 2 minutes).
Children (12 years): As in adults.
Hepatic impairment: Not recommended in serious liver disease; caution required.
Renal impairment: Caution in severe kidney disease; dose adjustment may be needed.
Side effects
Common side effects: Weakness, opioid withdrawal syndrome, anxiety, nervousness, dizziness, headache, sleepiness, diarrhea, nausea, vomiting, abdominal pain.
Serious side effects: Respiratory depression (especially with first use, dose increases, elderly, or lung disease).
Withdrawal symptoms (if stopped suddenly): Nausea, vomiting, diarrhea, muscle aches, sweating, anxiety.
Use in pregnancy
May be unsafe during pregnancy (Category C). Limited human data; animal studies show adverse fetal effects. Prolonged opioid use during pregnancy may cause neonatal opioid withdrawal syndrome (NOWS). Your doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Opioid medicines can cause respiratory depression; special caution needed with first use and dose increases.
- Do not stop abruptly (may cause withdrawal symptoms); gradually reduce dose with your doctor's guidance.
- May cause dizziness and sleepiness; avoid driving or tasks requiring concentration.
- Using with alcohol or other sedative medications increases risk of respiratory depression and overdose.
- Caution during pregnancy and lactation.
- Avoid use in serious liver disease; caution in hepatic and renal impairment.
Overdose effects
Overdose symptoms: Respiratory depression, extreme drowsiness, confusion, muscle weakness, cold and clammy skin, pinpoint pupils. Seek immediate medical attention if overdose is suspected.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.