৳ 15/unit
Pack: ৳ 150
৳ 15/unit
Pack: ৳ 150
At a glance
Dextromethorphan + Bupropion is a combination medication used for the treatment of Major Depressive Disorder (MDD) in adults.
Indications
- Major Depressive Disorder (MDD) in adults
Pharmacology
Dextromethorphan is an uncompetitive antagonist of the NMDA receptor and a sigma-1 receptor agonist. Bupropion increases plasma levels of Dextromethorphan by competitively inhibiting cytochrome P450 2D6. Bupropion is a relatively weak inhibitor of the neuronal reuptake of norepinephrine and dopamine and does not inhibit monoamine oxidase or the reuptake of serotonin.
Dosage
Adult: One tablet once daily in the morning for first 3 days; then increase to one tablet twice daily (at least 8 hours apart). Do not exceed two doses in the same day.
Moderate renal impairment: One tablet once daily in the morning.
Strong CYP2D6 inhibitors: One tablet once daily in the morning.
Side effects
Common: Dizziness, headache, somnolence, diarrhea, dry mouth, sexual dysfunction, hyperhidrosis.
Use in pregnancy
Insufficient clinical data on use during pregnancy. First trimester bupropion exposure has not been identified with increased risk of congenital malformations overall.
Pregnancy Category: N/A — always consult a doctor before taking during pregnancy.
Precautions & warnings
Seizure risk is dose-related; discontinue if seizure occurs. Increased blood pressure and hypertension may occur; assess blood pressure before and during treatment. Screen for bipolar disorder. Instruct patients to contact healthcare provider if psychosis or other neuropsychiatric reactions occur.
Overdose effects
Overdose may produce effects of individual components; overdose may be more severe or persistent due to bupropion inhibiting dextromethorphan metabolism.
Storage conditions
Store at or below 30°C. Keep away from light and moisture. Keep out of reach of children.