৳ 150/unit
Pack: ৳ 150
৳ 150/unit
Pack: ৳ 150
At a glance
Carbetocin is a synthetic oxytocin analogue used for the prevention of uterine atony and excessive bleeding following caesarean section. It binds to oxytocin receptors on uterine smooth muscle, causing uterine contractions.
Indications
- Prevention of uterine atony after caesarean section
- Prevention of excessive bleeding (postpartum hemorrhage) after caesarean section
Pharmacology
Carbetocin is a synthetic analogue of oxytocin reported to have a longer duration of action. It binds to oxytocin receptors on uterine smooth muscle, causing uterine contractions, which helps prevent uterine atony and postpartum hemorrhage. Carbetocin's longer duration of action makes it effective as a single dose compared to oxytocin.
Dosage
Adults: A single dose of 100 mcg IV bolus (slowly over 1 minute) administered within 1 minute after delivery following caesarean section.
Children: Not intended for use in children.
Note: Single dose only. Administer only after the infant has been delivered by caesarean section under epidural or spinal anaesthesia.
Side effects
Common (10-40% of patients): Nausea, vomiting, abdominal pain, pruritus (itching), increased body temperature, trembling, weakness.
Infrequent (1-5% of patients): Back pain, dizziness, metallic taste, anaemia, sweating, chest pain, dyspnoea, chills, tachycardia, anxiety, flushing, feeling of warmth, hypotension, headache.
Use in pregnancy
Contraindicated during pregnancy (do not administer before delivery). Inappropriate use during pregnancy may cause oxytocin overdosage symptoms (uterine hyperstimulation, tetanic contractions, uterine rupture, foetal hypoxia, etc.).
Precautions & warnings
- If adequate uterine contraction is not achieved after a single dose, additional doses of oxytocin or ergometrine may be required.
- Monitor blood pressure in patients with eclampsia and pre-eclampsia for up to 8 hours.
- Do not repeat treatment for inadequate uterine contraction (use additional oxytocin/ergometrine instead).
- Use with caution in epilepsy, migraine, asthma, or any condition where rapid addition to extracellular water may be hazardous.
- Not recommended for use in elderly patients.
- Carbetocin is structurally related to oxytocin; hyponatremia may occur.
Overdose effects
Overdosage can be expected to produce enhanced pharmacological effects associated with uterine hyperactivity and pain. Treatment: Symptomatic and supportive management.
Storage conditions
Store at 2-8°C. Do not freeze. Keep away from light. Once the ampoule has been opened, use immediately.