৳ 50/unit
Pack: ৳ 1,500
৳ 50/unit
Pack: ৳ 1,500
At a glance
Indacaterol + Glycopyrronium is used for long-term maintenance bronchodilator treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD).
Indications
- Long-term maintenance bronchodilator treatment of airflow obstruction in COPD patients (including chronic bronchitis and emphysema)
Pharmacology
Indacaterol is a long-acting beta2-adrenergic agonist that stimulates intracellular adenyl cyclase, catalyzing conversion of ATP to cyclic AMP. Increased cyclic AMP levels cause relaxation of bronchial smooth muscle. Glycopyrronium is a long-acting muscarinic antagonist (anticholinergic) that exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation.
Dosage
Adult Dose (Inhalation):
- COPD: 1 inhalation once daily (1 capsule)
- Use at the same time every day; not more than 1 time every 24 hours
- Not for relief of acute bronchospasm or treatment of asthma
Geriatric (≥65 years): Use at recommended dose
Children & Adolescents: Safety and efficacy not established (17 years and younger)
Renal Impairment: Mild-moderate: recommended dose; severe or ESRD (eGFR <30): use only if benefit outweighs risk
Hepatic Impairment: Mild-moderate: recommended dose; severe: caution
Side effects
Most Common (>3% and greater than placebo):
- Cough
- Oropharyngeal pain (including throat irritation)
Others: Indigestion, high blood pressure, nasopharyngitis, chest pain, fever, urinary retention, sore throat, headache, dizziness, allergic reaction, increased blood glucose, sinus inflammation, urinary tract infection
Use in pregnancy
Use in Pregnancy: Category C; no data from use in pregnant women; use only if expected benefit justifies potential risk to fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- LABA monotherapy increases risk of serious asthma-related events
- Do not initiate in acutely deteriorating COPD or asthma
- Do not use to treat acute symptoms
- If paradoxical bronchospasm occurs, discontinue
- Caution in cardiovascular disorders, convulsive disorders, thyrotoxicosis, diabetes mellitus
- Caution in narrow-angle glaucoma or prostatic hyperplasia
- Be alert to hypokalemia and hyperglycemia
Overdose effects
Overdose: May cause tachycardia, tremor, palpitations, headache, nausea, vomiting, drowsiness, ventricular arrhythmias, metabolic acidosis, hypokalemia, hyperglycemia or anticholinergic effects; supportive and symptomatic treatment; serious cases require hospitalization.
Storage conditions
Avoid storage in direct sunlight or heat; store in a cool & dry place; keep away from eyes; keep out of reach of children.