Cefaclav
125mg+31.25mg/5mlRx৳ 265/unit
Pack: ৳ 265
৳ 265/unit
Pack: ৳ 265
At a glance
Cefuroxime + Clavulanic Acid is a combination antibiotic used to treat various types of bacterial infections and prevents the growth and further spread of microorganisms.
Indications
- Pharyngitis/Tonsillitis
- Acute Bacterial Otitis Media
- Acute Bacterial Maxillary Sinusitis
- Lower Respiratory Tract Infections (including pneumonia)
- Acute Bacterial Exacerbation of Chronic Bronchitis
- Secondary Bacterial Infections of Acute Bronchitis
- Uncomplicated Skin and Skin Structure Infections
- Uncomplicated Urinary Tract Infections
- Bone and Joint Infections
- Uncomplicated Gonorrhea
- Early Lyme Disease
- Septicemia
- Meningitis
Pharmacology
Cefuroxime is a bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process.
Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. It has similar structure to beta lactam antibiotics which binds irreversibly to beta-lactamase enzymes and inactivates them. Clavulanic acid gives protection of Cefuroxime from degradation by beta lactamase enzymes and provides a solution for the treatment of bacterial infections caused by beta lactam resistant bacteria.
Dosage
Adult Dose (13 years and older - Oral):
| Infection Type | Dose | Schedule | Duration |
|---|---|---|---|
| Pharyngitis/Tonsillitis | 250 mg | Twice daily | 5-10 days |
| Acute Bacterial Sinusitis | 250 mg | Twice daily | 10 days |
| Acute Exacerbation of Chronic Bronchitis | 250-500 mg | Twice daily | 10 days |
| Secondary Bronchitis Infections | 250-500 mg | Twice daily | 5-10 days |
| Community Acquired Pneumonia | 250-500 mg | Twice daily | 5-10 days |
| Skin & Skin Structure Infections | 250-500 mg | Twice daily | 10 days |
| MDR Typhoid Fever | 500 mg | Twice daily | 10-14 days |
| Uncomplicated UTI | 250 mg | Twice daily | 7-10 days |
| Uncomplicated Gonorrhea | 1000 mg | Single dose | — |
| Early Lyme Disease | 500 mg | Twice daily | 20 days |
Pediatric Dose (3 months-12 years - Oral):
| Infection Type | Dose | Schedule | Duration |
|---|---|---|---|
| Pharyngitis/Tonsillitis | 20 mg/kg/day | Twice daily | 5-10 days |
| Otitis Media, Sinusitis, Impetigo | 30 mg/kg/day | Twice daily | 10 days |
| Community Acquired Pneumonia | 30 mg/kg/day | Twice daily | 5-10 days |
| MDR Typhoid Fever | 30 mg/kg/day | Twice daily | 10-14 days |
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Diarrhea
- Increased liver enzymes
- Allergic reaction
- Abdominal discomfort or pain
Use in pregnancy
[SAFE IF PRESCRIBED] Cefuroxime + Clavulanic Acid is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Pregnancy Category B. While all antibiotics should be avoided in the first trimester if possible, it can be safely used in later pregnancy.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [NOT RELEVANT] Cefuroxime + Clavulanic Acid is intended for use in hospitalized patients, so driving warnings do not apply.
- You have been prescribed this combination medicine to treat bacterial infections, even if they have developed resistance.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Take it with food to avoid an upset stomach.
- Diarrhea may occur as a side effect. Taking probiotics may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
- Stop taking Cefuroxime + Clavulanic Acid and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
- Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.
- Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis.
Overdose effects
Information on Cefuroxime + Clavulanic Acid overdosage is not available.
Storage conditions
Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.