৳ 2,500/unit
Pack: ৳ 2,500
৳ 2,500/unit
Pack: ৳ 2,500
At a glance
Cetrorelix is an anti-gonadotropin-releasing hormone medicine used in the treatment of infertility in females by restricting egg release and preventing premature ovulation.
Indications
- Female infertility
- Prevention of premature ovulation in assisted reproductive technologies
Pharmacology
Cetrorelix Acetate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. Cetrorelix Acetate blocks the effects of GnRH. GnRH controls the secretion of luteinizing hormone (LH), which induces ovulation during the menstrual cycle. During hormone treatment for ovarian stimulation, premature ovulation may lead to eggs that are not suitable for fertilization. Cetrorelix Acetate blocks such undesirable premature ovulation. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotropic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently luteinization as indicated by rising progesterone levels.
Dosage
Adult Dose (Subcutaneous): Assisted reproductive technologies: 0.25 mg cetrorelix (as acetate) beginning on day 5 or 6 of ovarian stimulation in the morning or in the evening beginning on day 5, and continued until ovulation induction.
Renal Dose: Severe renal impairment: Contraindicated.
Side effects
Common Side Effects:
- Nausea
- Ovarian hyperstimulation syndrome (OHSS)
- Injection site reactions (pain, swelling, redness)
- Itching
- Irritation
- Vomiting
- Lower abdominal pain
Use in pregnancy
[UNSAFE] Cetrorelix is highly unsafe to use during pregnancy. Studies on pregnant women and animals have shown significant harmful effects to the developing baby. Seek your doctor's advice.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [SAFE] Cetrorelix does not usually affect your ability to drive.
- Cetrorelix helps prevent premature ovulation in women undergoing assisted reproduction treatments such as IVF.
- It is given as an injection under the skin (subcutaneously), preferably of the upper leg.
- Inform your doctor immediately if you get very dizzy, faint, vomit, or have diarrhea while using this medicine. These could be symptoms of ovarian hyperstimulation syndrome (OHSS).
- Do not use this medicine if you are already pregnant or breastfeeding.
Overdose effects
If you think you have taken too much Cetrorelix, contact your healthcare professional, hospital emergency department or regional poison control centre immediately, even if there are no symptoms.
Storage conditions
Use immediately after reconstitution. Store in a refrigerator (2°C to 8°C). Do not freeze. Keep away from light & wet place. Keep out of reach of children.