৳ 2/unit
Pack: ৳ 2
৳ 2/unit
Pack: ৳ 2
At a glance
Chloramphenicol is an antibiotic that fights bacteria. It is used to treat certain types of serious infections caused by bacteria when other antibiotics cannot be used.
Indications
- Serious bacterial infections
- Typhoid fever
- Meningitis
- Haemophilus influenzae infections
Pharmacology
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.
Dosage
Adult Dose (Oral): 50 mg/kg/day in 4 divided doses, may increase to 100 mg/kg/day in more severe infections.
Pediatric Dose (Oral):
- Premature and full-term neonates: 25 mg/kg/day in 4 divided doses
- Full-term infants >2 weeks: 50 mg/kg/day in 4 divided doses
- Children: 50-75 mg/kg/day in 4 divided doses; 75-100 mg/kg/day for meningitis or severe infections
Hepatic Impairment: Dose reduction may be required.
Renal Impairment: Dose reduction may be required.
Side effects
Common Side Effects:
- Vomiting
- Nausea
- Diarrhea
- Taste change
Serious Side Effects: Bone marrow depression (irreversible aplastic anemia), gray baby syndrome (neonates), blood dyscrasias.
Use in pregnancy
[CONSULT YOUR DOCTOR] Chloramphenicol may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Precautions & warnings
- [UNSAFE] Chloramphenicol may cause blurring of your vision for a short time just after its use. Do not drive until your vision is clear.
- Your doctor has prescribed Chloramphenicol to cure your infection and improve your symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Your doctor may get blood tests done to check your blood cells before starting treatment and regularly thereafter.
- Do not use Chloramphenicol if you are pregnant, planning to conceive, or breastfeeding.
- Inform your doctor if you have liver or kidney disease.
- Avoid consuming alcohol as it may cause a Disulfiram-like reaction.
Overdose effects
Chloramphenicol overdose may cause bone marrow depression, nausea, vomiting, diarrhea, and abdominal pain. In case of overdose, symptomatic and supportive treatment should be given.
Storage conditions
Store in a cool and dry place, protected from light. Keep out of reach of children.