৳ 10/unit
Pack: ৳ 100
৳ 10/unit
Pack: ৳ 100
At a glance
Clonidine Hydrochloride is a centrally acting antihypertensive medication used for the treatment of hypertension, migraine prevention, menopausal flushing, and ADHD.
Indications
- Hypertension (high blood pressure)
- Migraine prophylaxis
- Menopausal flushing
- Opioid and alcohol withdrawal syndrome
- Attention Deficit Hyperactivity Disorder (ADHD)
Pharmacology
Clonidine Hydrochloride stimulates alpha adrenoceptors in the brain stem. With immediate-release clonidine, blood pressure declines within 30 to 60 minutes after an oral dose, the maximum decrease occurring within 2 to 4 hours. Renal blood flow and glomerular filtration rate remain essentially unchanged. Normal postural reflexes are intact; therefore, orthostatic symptoms are mild and infrequent.
Dosage
Adult Dose (Oral - Hypertension): Initial: 50-100 mcg three times daily, increased every 2nd or 3rd day; Maintenance: 300-1200 mcg/day; Max: 2400 mcg/day.
Adult Dose (Migraine prophylaxis/Menopausal flushing): 50 mcg twice daily, increased to 75 mcg twice daily if no remission after 2 weeks.
ADHD: IR: 5 mcg/kg/day; ER: 0.1 mg/day for 8 weeks.
Alcohol withdrawal: 0.3-0.6 mg every 6 hours.
Pediatric Dose (<12 years): Safety and efficacy not established.
Renal Dose: CrCl <10 mL/min: 50-75% of usual dose.
Side effects
Common Side Effects (dose-related):
- Dizziness
- Sleepiness
- Dry mouth
- Constipation
- Sedation
- Ear pain
- Irritability
- Diarrhea
- Abdominal pain
- Nausea
Use in pregnancy
[CONSULT YOUR DOCTOR] Clonidine Hydrochloride may be unsafe to use during pregnancy. Pregnancy Category C.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [UNSAFE] Clonidine Hydrochloride may cause blurring of your vision for a short time just after its use. Do not drive until your vision is clear.
- May cause dizziness or sleepiness; avoid driving or activities requiring concentration.
- Rise slowly if you have been sitting or lying down (orthostatic hypotension).
- May cause dryness of eyes; caution while using contact lenses.
- Do not stop suddenly without consulting your doctor (withdrawal symptoms: nervousness, agitation, headache, tremor, rapid rise in blood pressure).
- Caution during pregnancy and lactation.
Overdose effects
Overdose symptoms: Hypotension, Bradycardia, Respiratory Depression, Hypothermia, Sedation, Abnormal Reflexes, Weakness & Miosis.
Storage conditions
Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.