Clozam10mg
Rx- Generic:
- Clobazam
- Company:
- Navana Pharmaceuticals Ltd.
- Dosage form:
- Tablet
- Pack size:
- Strip (10 Tablet)
৳ 2.81/unit
Pack: ৳ 28.10
At a glance
Clobazam — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Clobazam belongs to a class of medicines known as benzodiazepines. It is a prescription medicine used to treat epilepsy (seizures) and severe anxiety. It alters brain activity, calms it and provides relief from panic attacks by relaxing the nerves. Clobazam may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it has a high potential of habit forming. If you have missed a dose, take it as soon as you remember and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may increase seizure frequency. Some common side effects of this medicine include tiredness, slurred speech, fever, cough, drooling, constipation, and difficulty in passing urine. It may cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is important to consult the doctor if you notice blisters on the skin or inside your mouth. If you have been taking this medicine for a long time than regular monitoring of blood and liver functions may be required. Clobazam is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.
Indications
• Severe anxiety • Epilepsy/Seizures
Mechanism of action
Clobazam binds to one or more specific GABA receptors at several sites within the CNS including the limbic system and reticular formation. Increased permeability of neuronal membrane to chloride ions results in GABA's inhibitory effect leading to hyperpolarisation and stabilisation.
Dosage
Adult Dose: Seizures Indicated for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients aged 2 years or older >30 kg: Initiate at 5 mg PO q12hr; may titrate as tolerated up to 40 mg/day divided q12hr Dose escalation should not proceed more rapidly than once weekly Hepatic impairment Limited data to characterize the effect of hepatic impairment on the pharmacokinetics; proceed with low and slow titration Mild-to-moderate (Child-Pugh 5-9): Starting dose should be 5 mg/day and titrated according to weight, but to half the typical adult dose; additional titration to the maximum dose (20 mg/day or 40 mg/day), depending on the weight group may be started on day 21 Severe hepatic impairment: Not recommended Child Dose: Seizures Indicated for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients aged 2 years or older 30 kg Starting dose: 5 mg PO q12hr; titrate as tolerated up to 40 mg PO daily After 7 days, may increase to 10 mg PO q12hr; if needed, may increase to 20 mg PO q12hr after an additional 7 days Renal Dose: Renal impairment Mild or moderate renal impairment: No dose adjustment required Severe renal impairment or ESRD: No experience
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clobazam may be taken with or without food, but it is better to take it at a fixed time.
Side effects
Common: • Aggressive behavior • Breathing problems • Constipation • Cough • Difficulty in urination • Drooling • Fever • Insomnia (difficulty in sleeping) • Sleepiness • Slurred speech • Tiredness
Precautions & warnings
[UNSAFE] Clobazam may cause side effects which could affect your ability to drive. You may feel sleepy or have concentration or memory problems after taking Clobazam and this may affect your ability to drive. The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid consuming alcohol as it may increase dizziness and drowsiness. Inform your doctor if you are pregnant, planning to conceive or breastfeeding. Inform your doctor if you notice sores or blisters on your skin, lips, or inside your mouth. Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.
Contraindications
Hypersensitivity; history of drug dependence; myasthaenia gravis; pregnancy (1st trimester), lactation; serious liver damage; sleep apnoea syndrome; impaired respiratory function.
Drug interactions
Increased hepatic clearance of clobazam when administered with phenytoin, phenobarbital or carbamazepine. Cimetidine may increase levels of clobazam. Potentially Fatal: Concurrent alcohol, hypnotics and sedative antidepressants can potentiate CNS side effects of clobazam
Food interactions
[UNSAFE] Clobazam may cause excessive drowsiness with alcohol.
Use in pregnancy
[CONSULT YOUR DOCTOR] Clobazam may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Use in lactation
[CONSULT YOUR DOCTOR] Clobazam is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Short-term use is not expected to cause any adverse effects in the breastfed baby, especially if the baby is older than 2 months. During long-term use, monitor for possible sleepiness.
Renal / hepatic impairment
[CAUTION] Clobazam should be used with caution in patients with kidney disease. Dose adjustment of Clobazam may be needed. Please consult your doctor. Limited information is available on the use of Clobazam in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease. [CAUTION] Clobazam should be used with caution in patients with liver disease. Dose adjustment of Clobazam may be needed. Please consult your doctor. Limited information is available on use of Clobazam in patients with severe liver disease.
Common questions
My father got paralysis stroke in april 2016 Now am giving him ecosprin av 150 telsarton 80 frisium 10 levera 150 eptoin 100 I feel doses going to much . In the morning 4 tablet and in the evening 5 tablets Frisium can be withdrawn Show to neurologist Epilepsy disorder for the past 7-8 years. Are contraceptive pills safe for epileptic patients Lamitor 25,50 and 100 epilive 500 Frisium 20 and frisium 5 per se epileptic ptinets can take contrcep pillswith these medicines; interaction is unlukelystill better talk to the gynec for other optionswheteher u hav epilepsy or not, pills are effective but can sometimes cause side effects due to hormonal effcets; personally i wud suggest barrier methods Is their any syruph OF FRISIUM insteed of Tablet What i know is no syrup is there Can I have Azithral 500 for my throat infection? I am on Valprin Chrono and Frisium for my epilepsy Visit ent specialist instead of starting medicine on your ownThere r different diagnosis for each symptom Defcult poor sleep due to anxiety Since 5 yr my consultant prescribed Frisium 5mg Nexito 10mg both medicine taking HS Kindly suggest Very poor Sleep I have to taking Tobacco Small quantities always day night Anxiety is the result of a hyperarousal state of nervous system due to a low threshold for threat perception. In simpler words, it's an ongoing flight or fight response. It can elicit a neuro-hormonal response understood as Flight or Fright reaction kicking in physiological cascade of symptoms ranging from palpitations, tachycardia, breathlessness, increased bowel movement, increase frequency of urination, dizziness, muscle tension or pain, trembling, dizziness, blurring of vision to restlessness, confusion and fainting spells. Chronic stress causes prolonged anxiety response with the consequences of slowed me ration, lack of concentration, headaches, fluctuations in blood pressure and increased wear and tear of body tissues. Identifying your stressors, learning to deal with them, de stressing regularly by doing something that makes one feel good, yoga and meditation are some non pharmacological strategies to deal with it. If the condition is persisting for a long time, it's better to see a psychiatrist. Nexito is a good drug but 10 mg is the starting dose and may not be adequate. My daughter suffer with epilepsy since 5 yrs and EEG of mind are normal after taking 5 yr cource of medicine ,currently she takes trioptal syrup by novartis daily 6ml morning and evening both,earlier she also takes frisium 5 for 2 yrs ,now frisium stops since one yr,I want to that till what time she has to taken trioptal syrup trioptal may be slowly withdrawn under medical supervision I got epilepsy and my suggested me to take levipil 1g two times a day along with Frisium morning 1 and night 2. I don't know why I get so much anger on everyone. Any solution for this problem levipil may nedd to be reduced, talk to ur doctor