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At a glance

Olopatadine is an antihistamine and mast cell stabilizer used for allergic conjunctivitis (itchy, watery, red and swollen eyes) and allergic rhinitis. It blocks histamine H1 receptors and inhibits histamine release from mast cells.

Indications
  • Allergic conjunctivitis (itchy, watery, red and swollen eyes)
  • Vernal keratoconjunctivitis
  • Vernal keratitis
  • Blepharitis, blepharoconjunctivitis
  • Giant papillary conjunctivitis
  • Seasonal allergic rhinitis (nasal spray)
  • Allergic rhinitis and allergic skin conditions (tablet)
Pharmacology

Olopatadine blocks H1 receptors to prevent histamine effects and inhibits release of histamine and other inflammatory mediators (tryptase, prostaglandin D2, TNF-α, pro-inflammatory cytokines) from mast cells.

Dosage

Eye Drops:

  • 0.1%: 1 drop in affected eye twice daily (6-8 hours apart)
  • 0.2%: 1 drop in affected eye once daily
  • 0.7%: 1 drop in affected eye once daily

Nasal Spray:

  • 12 years+: 2 sprays per nostril twice daily
  • 6-11 years: 1 spray per nostril twice daily

Tablet: Adults: 5 mg twice daily; Children (7 years+): 5 mg twice daily

Side effects

Side Effects:

  • Headache (rare)
  • Asthenia
  • Blurred vision
  • Burning or stinging in eyes
  • Dry eye
  • Foreign body sensation
  • Hyperemia
  • Hypersensitivity
  • Keratitis
  • Lid edema
Use in pregnancy

Use in Pregnancy: Olopatadine may be unsafe during pregnancy; no teratogenic effects in animals, but adequate human studies not available.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Do not wear contact lenses if eye is red
  • Not for treatment of contact lens related irritation
  • Discontinue if allergic reaction occurs
  • Do not spray nasal spray into eyes
  • Use within 1 month of opening
  • Caution while driving (may cause blurred vision)
Overdose effects

No information on overdose; seek medical attention if excessive use.

Storage conditions

Store at room temperature; protect from light; use within 1 month of opening.

Olopatadine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.