৳ 35/unit
Pack: ৳ 700
৳ 35/unit
Pack: ৳ 700
At a glance
Vericiguat is indicated to reduce the risk of cardiovascular death and heart failure hospitalization following a hospitalization for heart failure or need for outpatient IV diuretics, in adults with symptomatic chronic HF and ejection fraction less than 45%.
Indications
- Symptomatic chronic heart failure (ejection fraction <45%)
Pharmacology
Vericiguat is a stimulator of soluble guanylate cyclase (sGC). When NO binds to sGC, the enzyme catalyzes the synthesis of intracellular cGMP, a second messenger that plays a role in the regulation of vascular tone, cardiac contractility, and cardiac remodeling. Heart failure is associated with impaired synthesis of NO and decreased activity of sGC.
Dosage
Adult Dose (Oral):
- Starting dose: 2.5 mg once daily with food
- Double the dose approximately every 2 weeks to reach target maintenance dose of 10 mg once daily, as tolerated
Side effects
Common Side Effects:
- Low blood pressure
- Low red blood cells (Anemia)
Use in pregnancy
Use in Pregnancy: Contraindicated; may cause fetal harm; exclude pregnancy and use effective contraception.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May cause fetal harm; exclude pregnancy and use effective contraception
- Concomitant use with PDE-5 inhibitors not recommended (potential for hypotension)
- Contraindicated with other sGC stimulators
Overdose effects
Symptoms: Hypotension.
Treatment: Symptomatic treatment; unlikely to be removed by hemodialysis (high protein binding).
Storage conditions
Keep below 30°C, away from light and moisture; keep out of reach of children.