৳ 4,849/unit
Pack: ৳ 4,849
৳ 4,849/unit
Pack: ৳ 4,849
At a glance
Ganciclovir is an antiviral medicine used for the treatment of acute herpetic keratitis.
Indications
- Acute herpetic keratitis (dendritic ulcers)
Pharmacology
Ganciclovir is a guanosine derivative that, upon phosphorylation, inhibits DNA replication by herpes simplex viruses (HSV). Ganciclovir is transformed by viral and cellular thymidine kinases (TK) to ganciclovir triphosphate, which acts as an antiviral agent by inhibiting the synthesis of viral DNA in two ways: competitive inhibition of viral DNA-polymerase and direct incorporation into viral primer strand DNA, resulting in DNA chain termination and prevention of DNA replication.
Dosage
Adult Dose:
- Ganciclovir eye gel 0.15%: 1 drop in the affected eye 5 times per day (approximately every 3 hours while awake) until the corneal ulcer heals.
- Then 1 drop 3 times per day for 7 days.
* Use as directed by the registered physician
Side effects
Common Side Effects:
- Blurred vision - 60%
- Eye irritation - 20%
- Punctate keratitis - 5%
- Conjunctival hyperemia - 5%
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy. Animal studies have shown harmful effects (teratogenic).
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- For ophthalmic use only.
- Do not wear contact lenses if you have signs of herpetic keratitis or during therapy.
- It may cause short term blurring of vision - be cautious while driving.
Overdose effects
Overdose: Overdose through local or accidental oral administration is not likely.
Storage conditions
Storage: Store at 15°C to 30°C in a dry place protected from light. Do not use more than one month after first opening. Keep out of reach of children.