৳ 28/unit
Pack: ৳ 28
৳ 28/unit
Pack: ৳ 28
At a glance
Phenoxymethyl Penicillin (Penicillin V) is an antibiotic used for bacterial infections of the ear, nose, throat, lower respiratory tract, skin, and soft tissues. It is also used for prophylaxis of rheumatic fever and prevention of infection after dental and oral surgical procedures in high-risk patients.
Indications
- Ear, nose, and throat infections (tonsillitis, pharyngitis, laryngitis, otitis media, sinusitis)
- Lower respiratory tract infections (bronchitis, pneumonia, bronchopneumonia)
- Group A beta-hemolytic streptococcal infections (scarlet fever, erysipelas, rheumatic fever)
- Skin infections (pyodermia, furunculosis, phlegmon, erysipeloid, erythema migrans)
- Bacterial lymphadenitis and lymphangitis
- Infections of the buccal cavity, gums, or jaws
- Prophylaxis of scarlet fever
- Prevention of rheumatic fever recurrences
- Prophylaxis of infection after dental and oral surgical procedures in high-risk patients
Pharmacology
Phenoxymethyl penicillin is acid-stable and absorbed from the small intestine. It inhibits cell wall mucopeptide biosynthesis, exerting bactericidal action. It is effective against sensitive organisms and most effective during active multiplication. It has a distinct advantage over penicillin G in resistance to gastric acid inactivation.
Dosage
Adult Dose (Oral):
- General infections: 250-500 mg every 6 hours
- Rheumatic fever prophylaxis: 250 mg twice daily
- Streptococcal infections (scarlet fever, erysipelas): 125-250 mg every 6-8 hours for 10 days
- Pneumococcal infections (otitis media): 250-500 mg every 6 hours until afebrile for at least 2 days
- Fusospirochetosis/Staphylococcal infections: 250-500 mg every 6-8 hours
Pediatric Dose (Oral):
- Children: 25-50 mg/kg/day every 6 hours
- Children (>1 year): 125-250 mg every 6 hours
- Infants (<1 year): 62.5-125 mg every 6 hours
Side effects
Common Side Effects:
- Skin rashes (urticaria, morbilliform or scarlatiniform rashes)
- Pruritus
- Eosinophilia
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Gastrointestinal disturbances
- Pseudomembranous colitis
- Anaphylactic reactions
- Angioneurotic edema
- Laryngeal edema
- Bronchial spasm
- Shock
- Leukopenia, granulocytopenia, agranulocytosis
- Hemolytic anemia
- Thrombocytopenia
- Pancytopenia
- Myelosuppression
- Drug-induced aseptic meningitis
- Encephalopathy (in overdose or renal impairment)
Use in pregnancy
Use in Pregnancy: Generally considered safe during pregnancy; animal studies have shown low or no adverse effects; limited human studies available.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Consider cross-allergy with cephalosporins
- Do not use in patients with severe GI disorders (with vomiting and diarrhea)
- Prolonged use may lead to proliferation of resistant organisms
- Consider sugar content in syrup for diabetic patients
- Risk of encephalopathy (in overdose or renal impairment)
Overdose effects
Phenoxymethylpenicillin has low toxicity; no acute toxicity from single multiple therapeutic dose. Risk of encephalopathy in overdose; treatment: discontinue medication; hemodialysis can eliminate phenoxymethylpenicillin.
Storage conditions
Store in a cool and dry place, protected from light.