Cytomis Kit200mg+200mcg
Rx- Generic:
- Mifepristone + Misoprostol
- Company:
- Incepta Pharmaceuticals Ltd.
- Dosage form:
- Tablet
- Pack size:
- Box (2 Tablet)
৳ 150/unit
Pack: ৳ 300
At a glance
Mifepristone + Misoprostol — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Mifepristone + Misoprostol is a combination of two medicines, which is used for medical abortion (terminating a pregnancy). This medicine blocks the action of progesterone, a female hormone required to maintain pregnancy and induce contractions in the uterus, which further helps in abortion. Mifepristone + Misoprostol should be taken with food or as your doctor's advice. You must start with dose of Mifepristone. It should be taken orally, by swallow the tablets whole with a drink of water. If you experience vomiting within 30 minutes of tablet intake, inform your doctor or take another tablet. The medicine may take 24- 48 hours to show its action and you might experience spotting or bleeding. After a period of 36-48 hours, you have take misoprostol tablets, either orally or vaginally. You are suggested to have proper rest after dose intake as it may cause severe stomach pain or vaginal bleeding leading to abortion. The most common side effects of this medicine include nausea, vomiting, diarrhea and stomach cramps. If these bother you, or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some side effects may mean you should inform your doctor immediately include heavy vaginal bleeding or abdominal pain. Before taking this medicine, tell your doctor if you have ever had an ectopic pregnancy, or you are breastfeeding or using intrauterine device. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must avoid strenuous activity like heavy exercise, running and driving while abortion as it can affect the bleeding. Your doctor may perform an ultrasound or pelvic examination to check for abortion completion. Mifepristone + Misoprostol is a combination of two medicines: Mifepristone and Misoprostol, which causes abortion. Mifepristone blocks the effects of progesterone, a natural female hormone which is needed for the pregnancy to sustain. Without this hormone, the lining of the uterus (womb) breaks down as it does during a menstrual period and stops the growth of the pregnancy. Mifepristone increases contractions of the uterus to cause abortion.
Indications
• Medical abortion
Mechanism of action
Mifepristone is a progesterone antagonist with antiglucocorticoid activity. It binds to the intracellular progesterone receptor where it competitively inhibits progesterone attachment. It is also a partial progesterone agonist. Misoprostol, a synthetic prostaglandin E1 analogue, exerts its antisecretory activity by directly acting on specific prostaglandin receptors found on the surface of gastric parietal cells. It exerts its protective effects on the mucosa by replacing the prostaglandins consumed during prostaglandin-inhibiting therapies e.g. NSAIDs.
Dosage
Adult Dose: Day 1 (First visit): Mifepristone administration Day 1 One tablet of Mifepristone (200 mg) is taken in a single oral dose under the supervision of a qualified medical professional in a clinic, medical office or hospital. Day 2 (second visit): Misoprostol administration 24-48 hours after ingesting of Mifepristone tablet, the patient takes 4 tablets of 200 microgram (800 micrograms) of Misoprostol buccally. Misoprostol tablets can be administered by the patient herself (place two tablets on each side of cheek & gum). She should wait for 30 minutes. During the period immediately following the administration of Misoprostol, the patients may need medication for cramps or gestational symptoms. The patient should be given a phone number to call if she has questions following the administration of Misoprostol. Day 10 to 14 Patients must return to the clinic, medical office or hospital within 10 to 14 days after the administration of Mifepristone. This visit is very important to confirm by clinical examination or ultrasonographic scan that a complete termination of pregnancy has occurred. Patients who have an ongoing pregnancy at this visit have a risk of fetal malformation resulting from the treatment. Surgical termination/MVA (Manual vaccum Aspiration) is recommended to manage Menstrual Regulation (MR)/termination of pregnancy failures.
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mifepristone + Misoprostol is to be taken with food.
Side effects
Common: • Nausea • Vomiting • Diarrhea • Stomach cramp • Uterine contractions • Menorrhagia (heavy menstrual bleeding)
Precautions & warnings
[UNSAFE] Mifepristone + Misoprostol may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Mifepristone + Misoprostol helps terminate a pregnancy. Use caution while driving or doing anything that requires concentration as it can cause dizziness and sleepiness. It does not affect fertility. Use contraception to avoid pregnancy. For pregnancy termination:
Contraindications
Confirmed or suspected ectopic pregnancy, chronic adrenal failure, concurrent long-term corticosteroid therapy, history of allergy to mifepristone, misoprostol or other prostaglandin, haemorrhagic disorders or concurrent anticoagulant therapy, porphyria, hepatic or renal impairment; pregnancy and lactation; IUD in place; undiagnosed adnexal mass.
Drug interactions
Decreased efficacy with aspirin and NSAIDs. Efficacy of corticosteroids (including inhaled) decreased, monitor patients during co-admin and for several days afterwards. May increase effects of oxytocin. Increased risk of misoprostol-induced diarrhoea with magnesium-containing antacids.
Food interactions
[UNSAFE] It is unsafe to consume alcohol with Mifepristone + Misoprostol.
Use in pregnancy
[UNSAFE] Mifepristone + Misoprostol is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Use in lactation
[UNSAFE] Mifepristone + Misoprostol is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Renal / hepatic impairment
[CONSULT YOUR DOCTOR] There is limited information available on the use of Mifepristone + Misoprostol in patients with kidney disease. Please consult your doctor. [SAFE IF PRESCRIBED] Mifepristone + Misoprostol is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Mifepristone + Misoprostol may not be needed in these patients. Please consult your doctor.
Common questions
I missed my period 10 days and my pregnancy test is positive . Can I take unwanted kit or mife kit for self abortion. You can take it on your own risk, otherwise consult a nearby to know all the details. I'm 40 days pregnant. Can I use mankind unwanted kit? If so how to use? no u cam not use anyabortificient unless u have an ultrasound and u r sure ur preganacy is i the uterus. pregnancy test positive means u are pregnant but it does not tell u if ur pregnacy is uterine or outside. in case its not these pills vl not help i achieve abortion and it might be lifethreatening as well I took UNWANTED KIT pills without doctor consultant Is it safe or not ?? How do I release complete abortion. ? It is highly vomiting after taking unwanted pills plz help me ?? You need to consult a gynae nearby. I won't be able to prescribe you any Med on app I am pregnant since 2 month.i want to know can I take unwanted kit (from mankind) for aboition? Yes you can, though I would advise you to take such tablets under medical supervision to avoid any serious side effects. I am 25 days pregnant. Can i take unwanted abortion kit. I have two month breastfeeding baby. Is it harmfull for feeding baby Consult a Gynae. Don't take the kit without consulting your Dr. My wif use unwanted kit one day before but nothing is happend yet plz see a gyanec in person and get an ultrasound done Can i use mifty kit to avoid unwanted pregnancy, will it have any side effects? Am not aware of it Sir my girlfriend is pregnant 1 month!! Am use unwanted kit ok sir so my problem is slove or not ?? This kit is wrok or not sir ? Yes maybe But kindly think about the wrong things the youth of our country is heading to