৳ 180
৳ 45 /unit
৳ 180
৳ 45 /unit
At a glance
Cholecalciferol (Vitamin D3) is used for the treatment and prevention of Vitamin D3 deficiency. It is essential for the effective calcium and phosphate absorption required for healthy bones and teeth, preventing rickets, osteomalacia and osteoporosis.
Indications
- Vitamin D3 deficiency
- Rickets
- Osteomalacia
- Osteoporosis
- Pre-eclampsia prevention (pregnancy and lactation)
- Immunity boost
Pharmacology
The active form of Vitamin D3, Calcitriol, exerts its effect by binding to the Vitamin D receptors (VDRs). Vitamin D3 is absorbed in the small intestine and transported to the liver where it is metabolised to 25-hydroxy Vitamin D3 (Calcidiol). A second hydroxylation to 1,25-dihydroxy Vitamin D3 (Calcitriol) occurs in the kidney.
Dosage
Adult Dose (Capsule):
- Treatment of Vitamin D3 deficiency: 40,000 IU once weekly for 7 weeks; maintenance 1400-2000 IU/day
- Prevention of Vitamin D3 deficiency: 20,000 IU every 4 weeks
- Addition to specific therapy for osteoporosis: 20,000 IU once a month
Child Dose (12-18 years) (Capsule):
- Treatment of Vitamin D3 deficiency: 20,000 IU once every 2 weeks for 6 weeks
- Prevention of Vitamin D3 deficiency: 20,000 IU every 6 weeks
Film-coated Tablet: 1000 IU (1-2 tablets) daily
Injection: As directed by physician
Side effects
Common Side Effects:
- Hypocalcaemia syndrome or calcium intoxication
- Anorexia
- Headache
- Nausea
- Vomiting
- Abdominal pain
- Constipation
Use in pregnancy
Use in Pregnancy: Safe use of doses up to 4000 IU during pregnancy; recommended daily intake is 400 IU.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Plasma-calcium concentration should be monitored in patients receiving high doses, in renal impairment, and during pregnancy & lactation
- People using Digoxin and Thiazide Diuretics should consult a health care practitioner before supplementing
- People with liver or kidney disease, primary hyperthyroidism, lymphoma, tuberculosis and granulomatous disease should consult a health care practitioner
Overdose effects
Symptoms: Hypercalcaemia (nausea, vomiting, polyuria, anorexia, weakness, thirst, constipation).
Treatment: Stop all intakes of vitamin D and rehydration.
Storage conditions
Store in a cool (below 25°C) and dry place protected from light. Keep away from the reach of children.