৳ 150/unit
Pack: ৳ 2,100
৳ 150/unit
Pack: ৳ 2,100
At a glance
Daprodustat is a hypoxia-inducible factor, prolyl hydroxylase inhibitor (HIF-PHI) used for the treatment of anemia due to chronic kidney disease (CKD) in adults who have been receiving dialysis for at least four months.
Indications
- Anemia due to chronic kidney disease (CKD) in adults on dialysis for at least 4 months
Pharmacology
Daprodustat is a HIF-PHI. The activity of HIF-PH enzymes controls intracellular levels of HIF, a transcription factor that regulates the expression of genes involved in erythropoiesis. Through the reversible inhibition of HIF-PH, Daprodustat stimulates a coordinated erythropoietic response that includes the increase of plasma endogenous EPO levels, regulation of iron transporter proteins and reduction of hepcidin. This results in improved iron bioavailability, increased Hb production and increased red cell mass.
Dosage
Not on ESA: Hb <9 g/dL: 4 mg once daily; Hb 9-10 g/dL: 2 mg once daily; Hb >10 g/dL: 1 mg once daily.
Switching from ESA: Based on prior ESA dose, dose ranges from 4-12 mg once daily. Maximum dose: 24 mg once daily.
Moderate hepatic impairment: Reduce starting dose by half. Not recommended in severe hepatic impairment.
Side effects
Serious: Risk of hospitalization due to heart failure, high blood pressure, gastrointestinal erosion (damage to the lining of the stomach, esophagus, and intestines).
Use in pregnancy
May cause fetal harm. No adequate data in pregnant women. Use during pregnancy only if potential benefit justifies potential risk to the fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Increased risk of death, MI, stroke, VTE, & vascular access thrombosis; hospitalization for heart failure; hypertension; gastrointestinal erosion; serious adverse events in non-dialysis CKD patients; malignancy. May affect driving ability.
Overdose effects
Acute overdose may cause headache and gastrointestinal adverse reactions (e.g., nausea). No specific antidote. Hemodialysis will not substantially remove daprodustat (highly protein bound).
Storage conditions
Store below 30°C, in a cool and dry place. Keep away from light. Keep out of reach of children.