৳ 1,700/unit
Pack: ৳ 1,700
৳ 1,700/unit
Pack: ৳ 1,700
At a glance
Delafloxacin is a fluoroquinolone antibiotic used for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP).
Indications
- Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
- Community-Acquired Bacterial Pneumonia (CABP)
Pharmacology
Delafloxacin inhibits bacterial DNA topoisomerase IV and DNA gyrase (topoisomerase II) enzymes. It interferes with bacterial DNA replication and exerts concentration-dependent bactericidal activity.
Dosage
Adult - ABSSSI: 300 mg IV every 12 hours for 5-14 days; OR 450 mg PO every 12 hours for 5-14 days.
Adult - CABP: 300 mg IV every 12 hours for 5-10 days.
Severe renal impairment (eGFR 15-29): 200 mg IV every 12 hours.
Side effects
Common (1-10%): Nausea (8%), diarrhea (8%), headache (3%), transaminase elevations (3%), vomiting (2%).
Other (<2%): Sinus tachycardia, palpitations, tinnitus, vertigo, blurred vision, infusion site reactions, abdominal pain, hypersensitivity, myalgia, dizziness, anxiety, insomnia, pruritus, rash.
Use in pregnancy
There are limited data on the use of Delafloxacin in pregnant women. Please consult your doctor.
Pregnancy Category: N/A — always consult a doctor before taking during pregnancy.
Precautions & warnings
Fluoroquinolones are associated with disabling and potentially irreversible serious reactions (tendinitis, tendon rupture, arthralgia, peripheral neuropathy, CNS effects). Risk of tendinitis and tendon rupture in all ages. Risk of peripheral neuropathy. CNS reactions (convulsions, increased intracranial pressure, hallucinations, depression, suicidal thoughts). May exacerbate muscle weakness in myasthenia gravis. Hypersensitivity reactions.
Overdose effects
Treatment of overdose should consist of observation and general supportive measures. Hemodialysis removes about 19% of Delafloxacin and 56% of SBECD.
Storage conditions
Store at 20°C-25°C in a dry place, protected from light. Reconstituted vial may be stored for up to 24 hours (refrigerated or at room temperature). Do not freeze.