৳ 250/unit
Pack: ৳ 250
৳ 250/unit
Pack: ৳ 250
At a glance
Deferoxamine is a parenteral iron chelator used for the treatment of acute iron intoxication and chronic iron overload due to transfusion-dependent anemias.
Indications
- Acute iron intoxication
- Chronic iron overload due to transfusion-dependent anemias
- Diagnosis of aluminum overload
- Chronic aluminum overload in End-Stage Renal Failure
Pharmacology
Deferoxamine binds trivalent (ferric) iron, forming ferrioxamine, a stable complex which is eliminated via the kidneys. 100 mg of deferoxamine is capable of binding approximately 8.5 mg of trivalent iron.
Dosage
Adult - Chronic iron overload: Subcutaneous or intravenous infusion. Dose is individualized. Maximum 6.0 grams in 24 hours.
Child: Dose is based on weight and clinical condition.
Side effects
Common: Flushing (sense of warmth in face, ears, neck and trunk), rash, decreased blood pressure, abdominal pain.
Serious: Visual and auditory disturbances, renal dysfunction, anaphylactoid reactions.
Use in pregnancy
Deferoxamine may be unsafe during pregnancy. Animal studies have shown reproductive toxicity. Should only be used if hazard of acute iron intoxication is greater than teratogenic hazard.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Rapid IV injection (exceeding 15 mg/kg/h) has produced flushing, urticaria, hypotension and shock. Caution while driving (dizziness, visual disturbances). Caution with Vitamin C (avoid high doses in heart failure patients).
Overdose effects
Since Deferoxamine is available only for parenteral administration, acute intoxication is unlikely to occur.
Storage conditions
Store between 15-25°C. Do not store above 25°C.