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At a glance

Desloratadine is an antihistamine used for the relief of symptoms associated with seasonal and perennial allergic rhinitis and chronic idiopathic urticaria.

Indications
  • Seasonal and perennial allergic rhinitis (sneezing, nasal discharge, itching, congestion, ocular itching, tearing, redness)
  • Chronic idiopathic urticaria (hives, itching)
Pharmacology

Desloratadine, the major active metabolite of Loratadine, is a non-sedating, long acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity. Desloratadine also inhibits histamine release from human mast cell.

Dosage

Adults & ≥12 years: 5 mg once daily.
Children 6-11 years: 2.5 mg (5 ml syrup) once daily.
Children 1-5 years: 1.25 mg (2.5 ml syrup) once daily.
Children 6-11 months: 1 mg (2 ml drops) once daily.
Hepatic or renal impairment: 5 mg every other day.

Side effects

Common: Sleepiness, headache, nausea, fatigue, dizziness, pharyngitis, dyspepsia, myalgia.

Use in pregnancy

Pregnancy Category C. The safe use of Desloratadine during pregnancy has not been established. Should be used only if clearly indicated.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings

Caution while driving (dizziness, sleepiness may occur). Avoid alcohol (may cause excessive drowsiness). Stop at least 3 days before allergy testing. Caution in liver and kidney disease.

Overdose effects

No clinically relevant adverse effects have been reported.

Storage conditions

Store below 30°C in a cool & dry place, protected from light. Keep out of reach of children.

Desloratadine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.