৳ 97/unit
Pack: ৳ 97
৳ 97/unit
Pack: ৳ 97
At a glance
Diclofenac Sodium 1% Topical is an NSAID gel used for local relief of pain and inflammation in rheumatoid arthritis, osteoarthritis, and musculoskeletal pain.
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Joint and muscular pains
- Local symptomatic relief of pain and inflammation
Pharmacology
Diclofenac Sodium is a phenylacetic acid derivative and a prototypical NSAID. It inhibits cyclooxygenase (COX)-1 and COX-2, thereby inhibiting prostaglandin synthesis. May also inhibit neutrophil aggregation/activation, inhibit chemotaxis, decrease proinflammatory cytokine level, and alter lymphocyte activity.
Dosage
Adult (Osteoarthritis): Apply 2 g (upper extremities)/4 g (lower extremities) every 6 hours; not to exceed 8 g/day to any single joint of upper extremities; 16 g/day to any single joint of lower extremities.
Adult (Pain and inflammation): As 1% gel: Apply onto affected area 3 or 4 times daily.
Side effects
Common (>10%): Dry skin (25-27%), rash (20-35%), contact dermatitis (19-33%), pain (15-26%), paresthesia (<20%), pruritus (52%), exfoliation (6-24%).
Occasional (1-10%): Hypertension, chest pain, skin ulcer, diarrhea, dyspepsia, alopecia, photosensitivity, edema, conjunctivitis, hematuria, asthma.
Use in pregnancy
Pregnancy Category C. Avoid use of NSAIDs after 30 weeks of gestation.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Caution in rare instances of peptic ulceration or GI bleeding. Elderly patients should be kept under close observation. Avoid contact with eyes or mucous membranes. Not to be taken by mouth.
Overdose effects
Treatment of overdose is symptomatic.
Storage conditions
Store below 25°C. Protect from light. Do not freeze.