৳ 12.50/unit
Pack: ৳ 12.50
৳ 12.50/unit
Pack: ৳ 12.50
At a glance
Glimepiride + Pioglitazone is a combination antidiabetic medicine used to control blood sugar in type 2 diabetes mellitus.
Indications
- Type 2 diabetes mellitus - as an adjunct to diet and exercise
- Patients already treated with a combination of Pioglitazone and a sulfonylurea
- Patients whose diabetes is not adequately controlled with a sulfonylurea alone
- Patients who have initially responded to Pioglitazone alone and require additional glycemic control
Pharmacology
Pioglitazone & Glimepiride combines two antihyperglycemic agents with different mechanisms of action to improve glycemic control in patients with type 2 diabetes. Pioglitazone, a member of the thiazolidinedione class, is an insulin-sensitizing agent that acts primarily by enhancing peripheral glucose utilization. It depends on the presence of insulin for its mechanism of action. The primary mechanism of action of Glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells.
Dosage
Adult Dose:
- 30 mg/2 mg OR 30 mg/4 mg: 1 tab once daily, titrate gradually as needed
- Elderly: Start with glimepiride 1 mg/day prior to initiating combination
- Hepatic Impairment: ALT >2.5x ULN: Do not initiate
Renal Impairment (CrCl 22 mL/min): 30 mg/2 mg or 30 mg/4 mg once daily
* Use as directed by the registered physician
Side effects
Common Side Effects:
- Hypoglycemia (low blood sugar)
- Nausea
- Taste change
- Diarrhea
- Stomach pain
- Headache
- Edema (swelling)
- Weight gain
- Blurred vision
- Bone fracture
- Respiratory tract infection
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy. Animal studies have shown harmful effects.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Hypoglycemia may occur - always carry sugary food or fruit juice.
- Avoid alcohol (increases hypoglycemia risk).
- Risk of edema and heart failure - caution required.
- Regular liver function tests (ALT monitoring) required.
- Not recommended in severe liver disease.
Overdose effects
Overdose: Severe hypoglycemia with coma, seizure. Administer glucagon or IV glucose. Hypoglycemia may recur - continue monitoring.
Storage conditions
Storage: Store in a cool and dry place. Protect from light and moisture. Keep out of reach of children.