৳ 60/unit
Pack: ৳ 600
৳ 60/unit
Pack: ৳ 600
At a glance
Orlistat is a lipase inhibitor used for obesity. It blocks absorption of dietary fat from the stomach and small intestine to help with weight loss. It does not suppress appetite but limits fat absorption from food.
Indications
- Obesity (BMI >30 kg/m²)
- Overweight (BMI >28 kg/m²) with associated risk factors (type 2 diabetes, hyperlipidemia, hypertension)
Pharmacology
Orlistat binds to gastric and pancreatic lipases to inactivate them, preventing hydrolysis of dietary triglycerides into absorbable fatty acids and monoglycerides. Undigested triglycerides are excreted in feces, creating a caloric deficit for weight loss.
Dosage
Adult Dose (Oral):
- BMI >30 kg/m² or BMI >27 kg/m² with risk factors: 120 mg three times daily with each main meal
- BMI >28 kg/m² (regardless of risk factors): 60 mg three times daily
- Omit dose if meal is missed or contains no fat
- Discontinue if unable to lose 5% body weight in first 12 weeks
Pediatric Dose: Safety and efficacy not established in children <12 years
Side effects
Common Side Effects:
- Abdominal pain
- Fat in stool
- Flatus with discharge
- Oily spotting
- Diarrhea
- Abdominal cramp
- Flatulence
- Soft stools
Rare: Influenza, anxiety, headache, fatigue, hypersensitivity reactions (pruritus, exanthema, urticaria, angioedema, anaphylaxis)
Use in pregnancy
Use in Pregnancy: Orlistat is highly unsafe during pregnancy (Category X); definite evidence of severe fetal harm. Completely contraindicated.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Exclude organic causes of obesity (e.g., hypothyroidism) before starting
- Take fat-soluble vitamin (A, D, E, K) supplements
- Diabetic patients may need antidiabetic dose adjustment
- Separate cyclosporine by at least 2 hours
- Separate levothyroxine by at least 4 hours
- Monitor INR in warfarin patients
Overdose effects
Overdose: Systemic effects rapidly reversible; observe for 24 hours.
Storage conditions
Store in a cool and dry place below 30°C, protect from light & moisture; keep out of reach of children.