Digoxen200mcg
Rx- Generic:
- Digoxin
- Company:
- Drug International Ltd.
- Dosage form:
- Capsule
- Pack size:
- Capsule
৳ 1.34/unit
Pack: ৳ 1.34
At a glance
Digoxin — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Digoxin is a medicine used for the treatment of heart failure in combination with other medicines. It helps to provide symptomatic relief by making the heart pump blood more efficiently. This medicine is also used to treat abnormal heart rhythm (arrhythmia). Digoxin restores and maintains a normal and steady heartbeat. It should be taken regularly as advised by the doctor. You may take it with or without food but it is better to take this medicine at a fixed time. This medicine should not be stopped abruptly without consulting the doctor as this can worsen your condition. Regular follow-up with your doctor is advised while using this medicine. Common side effects of this medicine include nausea, vomiting, diarrhea, dizziness, and visual disturbances. Consult your doctor if these effects bother you. This medicine is used with caution for some people. Thus, you must inform the doctor if you are suffering from any kidney disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly. Your doctor may advise for regular monitoring of kidney function while you are taking this medicine. Digoxin is a cardiac glycoside. It works by correcting irregular heartbeat to a normal rhythm and increases the force with which the heart muscle contracts with every heartbeat. This makes the heart pump more efficiently and increases blood circulation throughout the body.
Indications
• Heart failure • Arrhythmia
Mechanism of action
Digoxin is a cardiac glycoside which has positive inotropic activity characterized by an increase in the force of myocardial contraction. It also reduces the conductivity of the heart through the atrioventricular (AV) node. Digoxin also exerts direct action on vascular smooth muscle and indirect effects mediated primarily by the autonomic nervous system and an increase in vagal activity.
Dosage
Adult Dose: Atrial Fibrillation Rapid digitalizing (loading-dose) regimen PO: 10-15 mcg/kg total loading dose; administer 50% initially; then may cautiously give 1/4 the loading dose q6-8hr twice; peform careful assessment of clinical response and toxicity before each dose Maintenance PO: 3.4-5.1 mcg/kg/day or 0.125-0.5 mg/day PO; may increase dose every 2 weeks based on clinical response, serum drug levels, and toxicity Heart Failure As per ACCF/AHA guidelines, a loading dose to initiate digoxin therapy in patients with heart failure is not necessary 0.125-0.25 mg PO/IV qDay; higher doses including 0.375-0.5 mg/day rarely needed Use lower end of dosing (0.125 mg/day) in patients with low lean body mass Child Dose: Heart Failure/Atrial Fibrillation Use doses at the lower end of the spectrm when treating heart failure Reduce dose by 20-25% when changing from oral formulation or IM to IV therapy Premature neonate PO: 1st loading dose, 10-15 mcg/kg; 2nd and 3rd loading doses, 5-7.5 mcg/kg q6-8hr for 2 doses; maintenance: 5-7.5 mcg/kg/day divided q12hr Full-term neonate PO: 1st loading dose, 12.5-17.5 mcg/kg; 2nd and 3rd loading doses, 6.25-8.75 mcg/kg q6-8hr for 2 doses; maintenance: 6-10 mcg/kg/day divided q12hr Infants & children 1-24 months PO: 1st loading dose, 17.5-30 mcg/kg; 2nd and 3rd loading doses, 8.75-15 mcg/kg q6-8hr for 2 doses; maintenance: 10-15 mcg/kg/day divided q12hr 2-5 years PO: 1st loading dose, 15-20 mcg/kg; 2nd and 3rd loading doses, 8.75-10 mcg/kg q6-8hr for 2 doses; maintenance: 7.5-10 mcg/kg/day divided q12hr 5-10 years PO: 1st loading dose, 10-17.5 mcg/kg; 2nd and 3rd loading doses, 5-8.75 mcg/kg q6-8hr for 2 doses; maintenance: 5-10 mcg/kg/day divided q12hr >10 years & <100 kg PO: 1st loading dose, 5-7.5 mcg/kg; 2nd and 3rd loading doses, 2.5-3.75 mcg/kg q6-8hr for 2 doses; maintenance: 2.5-5 mcg/kg/day Renal Dose: Use lower end of dosing (0.125 mg/day) in patients with impaired renal function
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Digoxin may be taken with or without food, but it is better to take it at a fixed time.
Missed dose
If you miss a dose of Digoxin, skip it and continue with your normal schedule. Do not double the dose.
Side effects
Common: • Visual impairment • Skin rash • Nausea • Vomiting • Diarrhea • Dizziness • Arrhythmia (irregular heartbeats)
Precautions & warnings
[UNSAFE] Digoxin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. . Take Digoxin at the same time every day. Notify your doctor about other medicines you're taking to avoid drug interactions. Symptoms of overdose include slow heartbeat, dizziness, lightheadedness and breathing problems. Do not discontinue use without consulting your doctor even if you feel better. Stopping abruptly could worsen your condition.
Contraindications
Digitalis toxicity, ventricular tachycardia/fibrillation, obstructive cardiomyopathy. Arrhythmias due to accessory pathways (e.g. Wolff-Parkinson-White syndrome).
Drug interactions
Effectiveness reduced by phenytoin, neomycin, sulphasalazine, kaolin, pectin, antacids and in patients receiving radiotherapy. Metoclopramide may alter the absorption of solid dosage forms of digoxin. Blood levels increased by calcium channel blockers, spironolactone, quinidine and calcium salts. Potentially Fatal: Electrolyte imbalances such as hypokalaemia and hypomagnesemia (e.g. admin of potassium-losing diuretics, corticosteroids) can increase the risk of cardiac toxicity.
Food interactions
[UNSAFE] It is unsafe to consume alcohol with Digoxin.
Use in pregnancy
[CONSULT YOUR DOCTOR] Digoxin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Use in lactation
[SAFE IF PRESCRIBED] Digoxin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Renal / hepatic impairment
[CAUTION] Digoxin should be used with caution in patients with kidney disease. Dose adjustment of Digoxin may be needed. Please consult your doctor. Regular monitoring of kidney function tests, potassium, magnesium and calcium levels is advisable while you are taking this medicine. [SAFE IF PRESCRIBED] Digoxin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Digoxin may not be needed in these patients. Please consult your doctor.
Common questions
LANOXIN 0.25 mg is not available what is the substitute digoxin 0.25 mg or Digitran 0.25 mg What for Nefrosave tablet is recommended ??? Nefrosave Tablet Uses Nefrosave Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: High Blood Pressure Join 148 Pro Subscribers Hereditary Disorder Affecting The Exocrine Glands Hepatitis Join 48 Pro Subscribers Carbon Tetrachloride Poisoning Join 75 Pro Subscribers Acute Bronchitis Join 74 Pro Subscribers Chronic Bronchitis Paracetamol Poisoning Congestive Heart Failure High Cholesterol Clotting in right leg.after trying tablet wefron2mg . Xerlton15mg is going on.but itching comes on full body. Itching not stopping.what may be reason for itching. Thodi sans bhi fulti he there ke kidney failure can be reason or heart attackconsult cardiologist and nephrologist What is BNP test? Pls explain. What is BNP ASSAY?My result is133.0 explain BNP levels below 100 pg/mL indicate no heart failure. BNP levels of 100-300 pg/mL suggest heart failure is present. BNP levels above 300 pg/mL indicate mild heart failure. BNP levels above 600 pg/mL indicate moderate heart failure.The level of BNP in the blood increases when heart failure symptoms worsen, and decreases when the heart failure condition is stable Myself is high B.P patients .There is some swelling in the face today . what is going on? Kidney damage or heart failure Having difficulty in getting full erections. I take concor 1.25 and roseday 10 as prescribed for arrhythmia. What can be prescribed to me ? Treatment for erectile dysfunction: 1.stop smoking and alcohol 2.join a gym and reduce weight. Do weight lifting exercises. 3.tablet sildenafil or viagra 1 tablet 1 hour before sexual activity. 4.Get tested so that u don?t have any of the following causes: 1.heart diseases 2. diabetes 3.neurological problems 4.hormonal problems 5.drug side effects