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At a glance

Dextromethorphan + Diphenhydramine + Levomenthol is an antitussive syrup used for the nighttime relief of persistent, dry, irritating cough.

Indications
  • Dry, irritating cough
  • Persistent nighttime cough
  • Aiding restful sleep
Pharmacology

Dextromethorphan is a non-opioid antitussive drug that acts on the cough centre in the medulla oblongata. Diphenhydramine possesses antitussive, antihistaminic, and anticholinergic properties. Levomenthol has mild local anaesthetic and decongestant properties.

Dosage

Adults and children aged 12 years and over: 2 teaspoonful at bedtime followed by 2 teaspoonful every 6 hours OR 2 teaspoonful 4 times a day. Do not take more than 4 doses (1 dose = 2 tsp) in 24 hours.

Side effects

Diphenhydramine: Drowsiness, dizziness, GI disturbance, dry mouth/nose/throat, difficulty in urination, blurred vision.
Dextromethorphan: Dizziness, nausea, vomiting, GI disturbance.

Use in pregnancy

Widespread use of dextromethorphan and diphenhydramine during pregnancy but insufficient data; use only if necessary.

Pregnancy Category: N/A — always consult a doctor before taking during pregnancy.

Precautions & warnings

May cause drowsiness; do not drive or operate machinery. Do not use in narrow-angle glaucoma or symptomatic prostatic hypertrophy. Caution in moderate-severe renal or hepatic dysfunction. Caution in CYP2D6 poor metabolizers or patients using CYP2D6 inhibitors.

Overdose effects

Overdose (especially in children) may cause hallucinations and convulsions; massive doses may cause coma or cardiovascular collapse; symptomatic treatment.

Storage conditions

Store at a temperature not exceeding 30°C in a dry place. Protect from light & moisture.

Dextromethorphan + Diphenhydramine + Levomenthol — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.