৳ 60/unit
Pack: ৳ 1,680
৳ 60/unit
Pack: ৳ 1,680
At a glance
Dienogest + Estradiol Valerate is a Hormone Replacement Therapy (HRT) used for the relief of post-menopausal symptoms including hot flushes and vaginal dryness.
Indications
- Post-menopausal symptoms (hot flushes, vaginal dryness)
- Complete stoppage of menstrual bleeding due to impending menopause
- Menopausal symptoms obstructing normal daily activities
Pharmacology
Estradiol valerate is an estrogen that controls elevated gonadotropin levels in postmenopausal women. Dienogest is a progestin that binds to the progesterone receptor, transforms the secretory function of the endometrium and protects against endometrial proliferation.
Dosage
Adult (Postmenopausal): 1 tablet daily at the same time, without interruption (28-day pack).
Side effects
Common (1-10%): Unexpected menstruation-like bleeding, breast tenderness/pain, headache, migraine, dizziness, tiredness, anxiety, depressive mood, hypertension, nausea, abdominal pain, diarrhea, increased gamma GT, endometrial thickening, hot flushes, weight changes.
Uncommon (0.1-1%): Insomnia, nervousness, vein inflammation, venous blood clot, constipation, bloating, increased sweating, hair loss, eczema, acne-like dermatitis.
Use in pregnancy
Pregnancy Category X. Do not use during pregnancy.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
HRT use increases risk of breast cancer, endometrial cancer, ovarian cancer, venous thromboembolism, heart disease and stroke. Caution in uterine fibroids, endometriosis, hypertension, diabetes, migraine, epilepsy, asthma, gallstones.
Overdose effects
Overdose may cause nausea, vomiting, and withdrawal bleeding; no specific antidote.
Storage conditions
Keep below 30°C temperature, away from light & moisture.