Drucil250mg/10ml
Rx- Generic:
- 5-Fluorouracil (5-FU)
- Company:
- Healthcare Pharmaceuticals Ltd.
- Dosage form:
- Injection
- Pack size:
- 250mg vial
৳ 100/unit
Pack: ৳ 100
Price comparison
- This brand
- ৳ 100
- Cheapest of this generic5-Fluril 250
- ৳ 55
The cheaper brand costs ৳ 45.00 less per unit
Compared against 3 brands
At a glance
5-Fluorouracil (5-FU) is an antimetabolite chemotherapy medication widely used in the management and treatment of various malignant neoplasms including colorectal, breast, gastric, pancreatic, liver, ovarian, lung, bladder, and cervical carcinoma. It interferes with DNA and RNA synthesis, slowing cancer cell growth and destroying them.
Indications
- Carcinoma of the colon or rectum
- Carcinoma of the stomach and exocrine pancreas
- Carcinoma of the liver
- Carcinoma of the breast
- Carcinoma of the bladder
- Carcinoma of the lung
- Epithelial ovarian carcinoma
- Cervical carcinoma
- Superficial basal cell carcinoma
- Esophageal carcinoma
Dosage
Adults:
IV Palliation (Malignant neoplasms): 12 mg/kg/day (max 0.8-1 g/day) for 3-4 days; if no toxicity, after 1 day, 6 mg/kg on alternate days for 3-4 doses. Repeat course after 4-6 weeks or maintenance doses of 5-15 mg/kg (max 1 g) weekly.
Colon, Breast, Ovary, Liver, Pancreas, Rectum, Stomach Cancer: 500 mg/m² IV on Days 1-5; OR 450-600 mg/m² weekly; OR 200-400 mg/m² continuous IV infusion (max 800 mg/day). Infusion: 15 mg/kg/day (max 1 g/day) until toxicity or total 12-15 g given.
Intra-arterial: 5-7.5 mg/kg/day as continuous infusion (regional perfusion).
Cervical cancer (with cisplatin): 1 g/m² IV on day 1; repeat every 21 days.
Poor risk and malnourished patients: 6 mg/kg/day for 3 days (max 400 mg/day); if no toxicity, 3 mg/kg on days 5,7,9.
Hepatic & Renal impairment: Dose reduction may be required.
Children: Safety and efficacy not established.
Side effects
Common side effects:
Increased risk of infection, mouth ulcer (stomatitis), vomiting, weakness, nausea, loss of appetite, hair loss, blisters on fingers/feet, decreased blood cells (RBC, WBC, platelets), diarrhea.
Hematological: Thrombocytopenia, leukopenia, anemia (may occur within first 10 days, resolves within 3 weeks).
Cardiac: Ischemic cardiac events (rare, may occur within hours of first dose).
Neurological: Cerebral ataxia (3.1-7%), acute cerebellar syndromes, myelopathy (intrathecal administration), conjunctivitis, tear duct stenosis, ectropion.
Hand-foot syndrome: Tingling, pain, redness, swelling or tenderness of hands and feet.
Allergic reactions: Difficulty breathing, swelling of lips/tongue/face, hives.
Precautions & warnings
- 5-Fluorouracil is a highly toxic drug with a narrow margin of safety; therapeutic response is unlikely without some evidence of toxicity.
- Daily dose should not exceed 1 gram.
- Discontinue promptly when signs of toxicity appear: Leukopenia (WBC <3500/mm³), Thrombocytopenia (platelets <100,000/mm³), Stomatitis (first small ulceration at inner margin of lips), Severe diarrhea, GI ulceration and bleeding.
- May cause nausea, dizziness, and visual changes; do not drive until you know how it affects you.
- Do not use during pregnancy and lactation.
- Regular blood tests (CBC) and liver function monitoring are required.