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At a glance

Difluprednate Eye Prep is a topical steroid used for the treatment of post-operative eye pain and inflammation.

Indications
  • Post-operative eye pain and inflammation
  • Uveitis
  • Pseudophakic cystoid macular edema (CME)
  • Blepharitis and corneal inflammation
Pharmacology

Corticosteroids inhibit the inflammatory response to a variety of inciting agents and may delay or slow healing. They inhibit edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.

Dosage

Post-operative inflammation & pain: 1 drop 4 times daily for 2 weeks starting 24 hours post-op; then 2 times daily for 1 week; then taper based on response.
Uveitis: 1 drop 4 times daily for 14 days; then taper as clinically indicated.
Blepharitis: 1 drop 2 times daily for 1 week, then once daily for 1 week.
Pseudophakic CME: 1 drop 2 times daily.

Side effects

Common: Eye irritation, burning sensation, watery eyes, corneal edema, ciliary and conjunctival hyperemia, eye pain, photophobia, posterior capsule opacification, anterior chamber cells, anterior chamber flare, conjunctival edema, blepharitis.
Serious: Elevated intraocular pressure (glaucoma), optic nerve damage, posterior subcapsular cataract formation, secondary ocular infection, corneal perforation.

Use in pregnancy

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings

Prolonged use may result in glaucoma and cataract formation; monitor IOP if used for 10 days or longer. Caution in patients with history of herpes simplex. Do not touch dropper tip to any surface.

Overdose effects

Overdosage will not ordinarily cause acute problems. If accidentally ingested, drink fluids to dilute.

Storage conditions

Store at room temperature, protect from light and freezing.

Difluprednate Eye Prep — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.