Epleron 50

• Hypertension: May be used alone or in combination with other antihypertensive agents.
• Heart Failure: Used for congestive heart failure after an acute myocardial infarction.
• Edema: Used to reduce swelling caused by fluid retention.

Eplerenone is a blocker of aldosterone binding at the mineralocorticoid receptor. It binds to the mineralocorticoid receptor and blocks the binding of aldosterone, a component of the renin-angiotensin-aldosterone-system (RAAS). Aldosterone synthesis, which occurs primarily in the adrenal gland, is modulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone and potassium.

Adult Dose:

• Hypertension: Initial 50 mg PO qDay; may increase to 50 mg PO q12hr. Full therapeutic response may take up to four weeks.
• Heart Failure Post MI: Initial 25 mg PO qDay; may titrate to maximum of 50 mg once daily within 4 weeks as tolerated.
• Hepatic Impairment: Dose adjustment not necessary.

Renal Dose: Contraindicated if CrCl <30 mL/min or serum creatinine >2 mg/dL (males) or >1.8 mg/dL (females).

Common Side Effects:

• Dizziness
• Diarrhea
• Nausea
• Cough
• Flu-like symptoms
• Fatigue
• Increased potassium level in blood
• Increased creatinine level in blood
• Abdominal pain
• Headache

Use in Pregnancy: Eplerenone is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Should be used only if clearly needed.

Precautions:

• Eplerenone may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
• It can make you feel dizzy for the first few days. Do not drive or do anything requiring concentration until you know how it affects you.
• It may increase the level of potassium in your blood. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
• Your doctor will regularly check your kidney function and the amount of potassium in your blood.
• Notify your doctor if you experience dizziness, diarrhea, vomiting, fast or irregular heartbeat, swelling in feet, or difficulty breathing.
• Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Overdose: Overdose may cause electrolyte imbalance, hyperkalemia, nausea, dizziness. In case of overdose, seek immediate medical attention and symptomatic treatment.

Storage: Store below 30°C in a cool and dry place, protected from light and moisture. Keep out of children's reach.