Erutic 50

Eplerenone is a medicine known as a diuretic (water pill). It is mainly used in the treatment of heart failure and high blood pressure. It is also used to reduce swelling (oedema) caused by some other conditions. Eplerenone can be taken with or without food, but you should take it in the same way each time to get the most benefit. Taking it with food can reduce some side effects and taking it early in the day can prevent you from having to get up at night to go to the toilet. You should keep using this medicine as it has been prescribed, even if you feel well. If you stop taking it, your condition may get worse. Follow your doctor's advice about the type and amount of liquids you should drink. If you are being treated for high blood pressure, lifestyle changes such as taking regular exercise and changes to your diet may increase the effectiveness of this medicine. The common side effects include nausea, dizziness, diarrhea, headache and cough. If these bother you, or appear serious, let your doctor know. There may be ways of reducing or preventing them. Drinking alcohol can increase certain side effects. You should be careful about using Eplerenone if you have kidney problems or are unable to urinate. Before taking it, tell your doctor if you have ever had kidney, liver or heart disease or you are pregnant. Also let your healthcare team know about all other medications you are using as they may affect, or be affected by this medicine. This medicine should only be used if it is clearly needed during pregnancy and while breastfeeding. While using this medicine, you may be advised to limit your intake of salt or salt substitutes, and you should have your blood pressure checked frequently. Some other tests will be done to monitor your progress. Eplerenone is a potassium-sparing diuretic. It lowers blood pressure and swelling by removing the extra water and electrolytes from the body without loss of potassium.

• Hypertension (high blood pressure) • Edema

Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g. kidney, GI tract) and nonepithelial (e.g. heart, blood vessels, brain) tissues; causing increases in blood pressure by inducing sodium reabsorption, vascular remodeling, water retention and possibly other mechanisms. Eplerenone is a relatively selective mineralocorticoid receptor antagonist, blocking binding of aldosterone and reducing blood pressure. Eplerenone also appears to have cardioprotective effect in patients with congestive heart failure (CHF) after myocardial infarction (MI).

Adult Dose: Hypertension (HTN) Initial 50 mg PO qDay; may increase to 50 mg PO q12hr; may take up to four weeks for full therapeutic response; hyperkelemia may occur with doses >100 mg/day Heart Failure Post MI Initial 25 mg PO qDay; may titrate to maximum of 50 mg once daily within 4 weeks as tolerated Dose adjustments may be required based on potassium levels Hepatic Impairment Dose adjustment not necessary Renal Dose: Renal Impairment Contraindicated if CrCl 2 mg/dL in males or >1.8 mg/dL in females

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Eplerenone may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Eplerenone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Dizziness • Diarrhea • Nausea • Cough • Flu-like symptoms • Fatigue • Increased potassium level in blood • Increased creatinine level in blood

[UNSAFE] Eplerenone may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Eplerenone helps remove fluid from your body when used with other drugs. It can make you feel dizzy for the first few days. Do not drive or do anything requiring concentration until you know how Eplerenone affects you. It may increase the level of potassium in your blood. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli. Your doctor will regularly check your kidney function and the amount of potassium in your blood while you are on this medicine. Notify your doctor if you experience dizziness, diarrhea, vomiting, fast or irregular heartbeat, swelling in feet, or difficulty breathing. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

For all patients: Serum potassium >5.5 mEq/L at initiation; CrCl ?30 mL/min; concomitant use of strong CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir). For patients treated for hypertension: Patients with type 2 DM with microalbuminuria; serum creatinine >2 mg/dL (male), or >1.8 mg/dL (female); CrCl <50 mL/min; concomitant use of potassium supplements or potassium-sparing diuretics (e.g. amiloride, spironolactone, or triamterene).

Concomitant use with CYP3A4 Inhibitors (e.g. ketoconazole, voriconazole, itraconazole, fluconazole, clarithromycin, diltiazem saquinavir, verpamil, ritonavir) may increase serum concentrations of Eplerenone. CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin, phenobarbital) may decrease Eplerenone efficacy. Eplerenone may enhance hyperkalaemic effect of ACE inhibitors, angiotensin II receptor blockers, potassium-sparing diuretics or potassium salts. Concomitant use with diazoxide, MAOIs, pentoxifylline, prostacyclin analogues may enhance hypotensive effect of antihypertensives. NSAIDs may possibly reduce the antihypertensive and/or diuretic effects of potassium-sparing diuretics and may increase risk of hyperkalaemia. Lithium toxicity has been reported when used with ACE inhibitors or diuretics; monitor lithium levels when used with Eplerenone.

[UNSAFE] Eplerenone may cause excessive drowsiness with alcohol.

[SAFE IF PRESCRIBED] Eplerenone is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[CONSULT YOUR DOCTOR] Information regarding the use of Eplerenone during breastfeeding is not available. Please consult your doctor.

[CAUTION] Eplerenone should be used with caution in patients with kidney disease. Dose adjustment of Eplerenone may be needed. Please consult your doctor. Use of Eplerenone is not recommended in patients with severe kidney disease. [CAUTION] Eplerenone should be used with caution in patients with liver disease. Dose adjustment of Eplerenone may be needed. Please consult your doctor. Use of Eplerenone is not recommended in patients with severe liver disease as the data available is limited.

I am a patient of hypertension Hypertension is clinal condition of high blood pressure. Please see a physician. Some times I had lot of hypertension Hypertension is clinically high blood pressure. Persistent high arterial blood pressure above 120/80 mm HG is termed as pre-hypertension or hypertension, but the point to be emphasized is that this rise in blood pressure is persistent. Transient increase in BP occurs in stress and anxiety and needs to be treated accordingly. High blood pressure, breathing issues Do yoga and pranayam regularly, take halleezy tablet 2 tablet twice Hypertension blood pressure pro Bp any medicine u taking Wait loss and high blood pressure Take medohar guggul 2 tab twice, vrikshamla tablet twice with water, do yoga and pranayam totally impotency due to diabetes and high blood pressure control ur sugars and b.ptake tablet dejac t 1 hr befr sex Which tablet is best for high blood pressure.I am taking telmisim 40 Which tablet is best for high blood pressure. I am taking telmisim 40 Depends on your blood pressure range kidney and heart functions To control->> high blood pressure Is &#x27;AMLOKIND- L&#x27; Tablet right substitute for &#x27;AMLOZAAR&#x27;? Yes u can take amlokind L