৳ 20/unit
Pack: ৳ 200
৳ 20/unit
Pack: ৳ 200
At a glance
Nitrofurantoin is an antibiotic used for treatment and prophylaxis of uncomplicated urinary tract infections. It kills bacteria in the urine to cure the infection.
Indications
- Acute uncomplicated urinary tract infections (caused by E. coli, Enterococci, S. aureus, S. saprophyticus, Klebsiella, Enterobacter)
- Prophylaxis of urinary tract infections
Pharmacology
Nitrofurantoin interferes with cell metabolism and cell wall synthesis by inhibiting several enzyme systems including acetyl coenzyme A, resulting in bacterial cell death.
Dosage
Adult Dose (Oral):
- Acute uncomplicated UTI: 50-100 mg 4 times daily for 7 days or 3 days after sterile urine; SR: 100 mg twice daily
- Prophylaxis: 50-100 mg at bedtime for up to 12 months
Pediatric Dose (>1 month):
- UTI: 5-7 mg/kg/day divided q6hr for 7 days
- Prophylaxis: 1-2 mg/kg at bedtime or 2 divided doses
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Diarrhea
- Headache
- Flatulence
- Dyspepsia
- Abdominal pain
- Constipation
- Dizziness, drowsiness
Use in pregnancy
Use in Pregnancy: Nitrofurantoin is safe during pregnancy (Category B); use only if clearly needed.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Discontinue if acute, sub-acute or chronic pulmonary reactions occur
- Do not take antacids containing magnesium trisilicate
- Caution in G6PD deficiency
- Caution in anemia, diabetes, electrolyte imbalance, vitamin B deficiency
- Caution while driving (may cause dizziness and drowsiness)
Overdose effects
Overdose: No specific symptoms other than vomiting; induction of emesis recommended.
Storage conditions
Do not store above 30°C; keep away from light; keep out of reach of children.